ANNOUNCEMENTS

We’re excited to share that Xona Microfluidics will be presenting a joint poster with our collaborators at Merakris Therapeutics at the upcoming AD/PD 2026 meeting in Copenhagen..

We’re excited to share that Xona Microfluidics will be presenting a joint poster with our collaborators at Merakris Therapeutics at the upcoming Society for Neuroscience (SfN) Annual Meeting in San Diego, California, on Tuesday, November 18, 2025.

Xona Microfluidics, Inc. (“Xona”) and Healx Limited (“Healx”) are pleased to announce a joint presentation at the Society for Neuroscience (SfN) Annual Meeting on Saturday afternoon, November 15, 2025, highlighting a new approach to testing regenerative therapeutics in human neurons using next-generation microfluidic technology.

Activation of microglia occurs in Alzheimer’s disease and is indicative of neuroninflammation. Recently we co-cultured human iPSC-derived cortical glutamatergic neurons expressing eGFP together with human iPSC-derived microglia (BrainXell) and found robust activation of microglia in response to the inflammatory molecule, LPS. Further data shows that neurons exhibit AD-like cellular pathology in response to this inflammatory insult.

Our newest X4 chip (catalog # XC-SF150-X4) uses fewer neurons per culture unit, thereby increasing sample size when using a finite amount of cells. Cell loading is also optimized and the chip is a great improvement for automated imaging studies. Recently we cultured hiPSC-derived motor neurons expressing eGFP (BrainXell, BX-0101)  for 27 days in our X4 chips. The result is the beautiful image in this post.

Increasing throughput continues to be an enormous need for neuron-based compartmentalized culture platforms. Current approaches using PDMS are not adequate to create higher density platforms because of registration issues due to shrinkage making automated imaging next to impossible. Xona Microfluidics has overcome this limitation by developing a new injection molded XonaChip called the X4 chip. This chip contains multiple sample units that are always the same location and size–a huge advance for automated imaging and drug discovery efforts. Further, these chips (the size of standard microscope slides) can be combined in a plate holder to yield sixteen (16) sample units. Check out this post to learn more.