Our newest X4 chip (catalog # XC-SF150-X4) uses fewer neurons per culture unit, thereby increasing sample size given a finite number of neurons. Cell loading is also optimized and the chip is a great improvement for automated imaging studies. Recently we cultured hiPSC-derived motor neurons expressing eGFP (BrainXell, BX-0101)  for 27 days in our X4 chips. The result is the beautiful image in this post. This image is a montage of multiple images taken using a spinning disk ImageXpress high content imaging system (Molecular Devices) using a 20x objective. Learn more about the X4 chip.

Check out our protocols page to learn more about how to use the X4 chip. To request a sample, please email info@xona.us.


Xona Microfluidics is a US-based company that makes compartmentalized microfluidic chambers for culturing neurons and creating co-culture and innervation models in vitro. Xona’s technology is also used to model multi-cellular environments for organ-on-a-chip or microphysiological system applications. Xona provides contract research services in addition to product sales, using our microfluidic platforms to develop scalable neuron-based assays. Our patented compartmentalized chip technology directs the growth of axons from a somatodendritic compartment to an isolated axonal compartment allowing distinct microenvironments within each compartment to be established. Xona sells compartmentalized microfluidic chambers in two formats: Preassembled XonaChips® and original Silicone (PDMS) Devices. Over 1,000 publications cite our compartmentalized microfluidic devices and chips. Many of these publications can be found on our publications page.


To learn more about products and research services provided by Xona, please contact us at info@xona.us.

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