Culture Neurons with
Xona Microfluidic Devices
Xona Microfluidics® provides high quality microfluidic devices for compartmentalizing neurons.
Our expert team includes neuroscientists with critical experience designing and conducting research. Xona has been awarded numerous NIH grants and, in 2020, began offering contract research services.
Xona holds the original, exclusive license to sell compartmentalized microfluidic devices, originally described in Nature Methods (2005). Dr. Anne Taylor, an inventor, is Xona’s Chief Scientific Officer.
Our microfluidic devices enable the unique study of neuronal subcellular compartments and lead to the development of valuable in vitro models of the NMJ and other co-culture innervation models. Our devices are used extensively for Alzheimer’s disease, ALS, and Parkinson’s disease research.
Xona’s time-tested technology has been cited in over 1,000 publications. Many of these publications can be found on our publications page.
Both primary neurons and human iPSC-derived neurons can be easily cultured within our platforms. Neurons can be cultured for 21 or more days. Xona Microfluidics® sells both the original Silicone (PDMS) Devices as well as our newer XonaChips® which are made of optically transparent cyclic olefin copolymer.
Latest News & Technotes
Increase throughput using Xona’s RD series Silicone (PDMS) Devices
Xona’s round microfluidic chambers were placed into 12-well plates increase throughput and sample size. Montage images of each well containing the microfluidic device illustrate how automated imaging can be performed in such a format.
Congratulations to Macquarie University for winning 2nd place in the 2021 Nikon Small World Photo competition!
Esmeralda Paric and Holly Stefen won 2nd place for their image of networking neurons in a microfluidic device (SND450). This is a truly impressive feat considering the extensive competition.
The Meyer’s lab (Indiana University) grows retinal ganglion cells (RGCs) in XonaChips®
Paper Highlight! RGCs expressing a fluorescent protein were purified from human pluripotent stem cell (hPSC) -derived organoids and then grown within XonaChips®, as detailed in a recent 2021 publication Stem Cell Reports from Jason Meyer’s lab at Indiana University.
3D cultures in XonaChips® used for high profile Alzheimer’s disease study
Paper Highlight! An impressive paper in Cell Reports from the Tanzi lab uses XonaChips® to create 3D compartmentalized cultures. ELISA was used to quantify Aβ levels using media isolated from the axonal compartment.
See videos featuring neurons cultured in XonaChips®
Introducing XonaChips®
Use XonaChips® to Compartmentalize Primary Murine Neurons
Use XonaChips® to Compartmentalize Stem Cell Derived Neurons
FLUIDIC ISOLATION OF AXONS
WITH CUSTOMIZED MICROENVIRONMENTS
XONA MICROFLUIDICS offers a wide selection of devices for neuron cell culture.
The pre-assembled, easy to use XonaChip® offers a high quality, reproducible method for the
compartmentalization, fluidic isolation and improved organization of neuronal cultures.
They are especially great for culturing human stem cell-derived neurons.
The XonaChip® offers the researcher a novel method to isolate and grow axons, ultimately delivering the ability to study neuronal response to axonal damage due to disease or injury in an isolated fluidic environment.