Latest News & Technotes
Introducing the X4 XonaChip® for Higher Throughput Applications
Increasing throughput continues to be an enormous need for neuron-based compartmentalized culture platforms. Current approaches using PDMS are not adequate to create higher density platforms because of registration issues due to shrinkage making automated imaging next to impossible. Xona Microfluidics has overcome this limitation by developing a new injection molded XonaChip called the X4 chip. This chip contains multiple sample units that are always the same location and size–a huge advance for automated imaging and drug discovery efforts. Further, these chips (the size of standard microscope slides) can be combined in a plate holder to yield sixteen (16) sample units. Check out this post to learn more.
Growing BrainXell hiPSC neurons in XonaChips® and Silicone (PDMS) Devices
eGFP-expressing human induced pluripotent stem cell (hiPSC) derived glutamatergic neurons from BrainXell grew for over 35 days in XonaChips® and Silicone Devices. Extensive axonal growth was observed by 7 days.
Xona Attends Triangle SfN Annual Meeting 2022 in Cary, North Carolina
Xona had a booth at the Triangle Society for Neuroscience (SfN) Annual Meeting in Cary on Sept. 9, 2022. We were pleased to attend sessions by prominent neuroscientists, and to inform attendees about Xona’s products and services. Xona provided free samples of its products to neuroscientists who requested them. We made great contacts regarding our contract research services, and look forward to future meetings and involvement with Triangle SfN!
Visit us at NECTAR 2022 in Athens, Greece!
Xona will be at NECTAR 2022 in Athens, Greece, October 24-26, 2022. Xona’s Chief Scientific Officer, Dr. Anne Taylor, will discuss applications of Xona’s devices and the XonaChip® to neuroscience research. Xona’s devices have been cited in over 1,000 scientific journals. Xona Microfluidics sells its devices worldwide, including the United Kingdom, Germany, France, Italy, and the rest of Europe.
See videos featuring neurons cultured in XonaChips®
Introducing XonaChips®
Use XonaChips® to Compartmentalize Primary Murine Neurons
Use XonaChips® to Compartmentalize Stem Cell Derived Neurons
Customize Neuronal Microenvironments with
Xona Microfluidic Devices
Xona Microfluidics® provides high quality microfluidic devices for compartmentalizing neurons.
Our expert team includes neuroscientists with critical experience designing and conducting research. Xona has been awarded numerous NIH grants and, in 2020, began offering contract research services.
Xona holds the original, exclusive license to sell compartmentalized microfluidic devices, originally described in Nature Methods (2005). Dr. Anne Taylor, an inventor, is Xona’s Chief Scientific Officer.
Our microfluidic devices enable the unique study of neuronal subcellular compartments and lead to the development of valuable in vitro models of the NMJ and other co-culture innervation models. Our devices are used extensively for Alzheimer’s disease, ALS, and Parkinson’s disease research.
Xona’s time-tested technology has been cited in over 1,000 publications. Many of these publications can be found on our publications page.
Both primary neurons and human iPSC-derived neurons can be easily cultured within our platforms. Neurons can be cultured for 21 or more days. Xona Microfluidics® sells both the original Silicone (PDMS) Devices as well as our newer XonaChips® which are made of optically transparent cyclic olefin copolymer.