Our newest X4 chip (catalog # XC-SF150-X4) uses fewer neurons per culture unit, thereby increasing sample size when using a finite amount of cells. Cell loading is also optimized and the chip is a great improvement for automated imaging studies. Recently we cultured hiPSC-derived motor neurons expressing eGFP (BrainXell, BX-0101) for 27 days in our X4 chips. The result is the beautiful image in this post.
Increasing throughput continues to be an enormous need for neuron-based compartmentalized culture platforms. Current approaches using PDMS are not adequate to create higher density platforms because of registration issues due to shrinkage making automated imaging next to impossible. Xona Microfluidics has overcome this limitation by developing a new injection molded XonaChip called the X4 chip. This chip contains multiple sample units that are always the same location and size–a huge advance for automated imaging and drug discovery efforts. Further, these chips (the size of standard microscope slides) can be combined in a plate holder to yield sixteen (16) sample units. Check out this post to learn more.
eGFP-expressing human induced pluripotent stem cell (hiPSC) derived glutamatergic neurons from BrainXell grew for over 35 days in XonaChips® and Silicone Devices. Extensive axonal growth was observed by 7 days.
Xona had a booth at the Triangle Society for Neuroscience (SfN) Annual Meeting in Cary on Sept. 9, 2022. We were pleased to attend sessions by prominent neuroscientists, and to inform attendees about Xona’s products and services. Xona provided free samples of its products to neuroscientists who requested them. We made great contacts regarding our contract research services, and look forward to future meetings and involvement with Triangle SfN!
Xona will be at NECTAR 2022 in Athens, Greece, October 24-26, 2022. Xona’s Chief Scientific Officer, Dr. Anne Taylor, will discuss applications of Xona’s devices and the XonaChip® to neuroscience research. Xona’s devices have been cited in over 1,000 scientific journals. Xona Microfluidics sells its devices worldwide, including the United Kingdom, Germany, France, Italy, and the rest of Europe.
We will have a booth at Alzheimer’s Association International Conference (AAIC) 2022 in San Diego July 30 to August 3. We hope to see you there!
We will be at FENS 2022 in Paris July 9-13th. Please join us! Xona sells devices worldwide, including the United Kingdom, Germany, France, Italy, and the rest of Europe.
How are XonaChips different from our Silicone Devices? In this Tech Note, we discuss the advantages of each type of compartmentalized microfluidic chamber so that you can decided which configuration is best for your application.
Xona sells devices worldwide, including the United Kingdom, Germany, France, Italy, and the rest of Europe. We will be at FENS 2022 in Paris July 9-13th. Please join us!
Xona introduces a new open compartment neuron culture device and microfluidic platform called the Innsbruck device. This Silicone (PDMS) Device is a compartmentalized microfluidic chamber with an enclosed center compartment and two open outer compartments.