ANNOUNCEMENTS
Congratulations to Macquarie University for winning 2nd place in the 2021 Nikon Small World Photo competition!
Esmeralda Paric and Holly Stefen won 2nd place for their image of networking neurons in a microfluidic device (SND450). This is a truly impressive feat considering the extensive competition.
The Meyer’s lab (Indiana University) grows retinal ganglion cells (RGCs) in XonaChips®
Paper Highlight! RGCs expressing a fluorescent protein were purified from human pluripotent stem cell (hPSC) -derived organoids and then grown within XonaChips®, as detailed in a recent 2021 publication Stem Cell Reports from Jason Meyer’s lab at Indiana University.
3D cultures in XonaChips® used for high profile Alzheimer’s disease study
Paper Highlight! An impressive paper in Cell Reports from the Tanzi lab uses XonaChips® to create 3D compartmentalized cultures. ELISA was used to quantify Aβ levels using media isolated from the axonal compartment.
Cellular model of human motor unit using XonaChips exhibits ALS disease hallmarks
Paper Highlight! The Van Den Bosch Lab (KU Leuven/VIB) creates in vitro human motor units using XonaChips®. These results were recently published in Stem Cell Reports April 2021.
Seeking collaborators!
Xona is actively looking for partners interested in screening/validating their target compound(s) using our cell-based tau mislocalization assay or similar assays for Alzheimer’s Disease (AD/ADRD) research. We have high content imaging capabilities and are planning to use 3D human iPSC-derived neuron cultures. Please contact us at info@xona.us to learn more. We are applying for a NIH/NIA SBIR for this development work.
New Product! Open compartment Silicone Devices
Xona now offers open compartment devices. Here we show a single open compartment Silicone Devices (SOC450).
Xona scientists present posters at SfN Global Connectome: A Virtual Event on Jan. 11
Xona scientists will present their latest research using compartmentalized devices to investigate (1) somatodendritic mislocalization of tau following axonal exposure to Aβ stress and (2) neuronal maturation of 3D cultures.
Culture ready EtO processed ChipTrays™ are now available
Xona Microfluidics, Inc. is now offering ethylene oxide (EtO) processed ChipTrays™ to house your XonaChips® and Silicone Devices during cell culture incubation.
Isolate microglia to axons using Xona devices
In an impressive new paper from the Yamashita lab, Fujita et al. (2020) use Xona's compartmentalized devices to test whether microglial accumulation to axons involves Netrin-G1 signaling. Fujita & Yamashita (2020) further published a STAR protocol detailing their...
Introducing XonaChips®
Xona Microfluidics, Inc. has developed a new easy-to-use microfluidic chip to compartmentalize neurons and establish microenvironments, called the XonaChips®. XonaChips® are made out of an optically transparent plastic, cyclic olefin copolymer, which allows us to offer fully assembled chips that require few preparation steps, and result in excellent neuronal growth.