Murata, H., Y. Yasui, K. Oiso, T. Ochi, N. Tomonobu, K.-i. Yamamoto, R. Kinoshita and M. Sakaguchi, 2023. STAT1/3 signaling suppresses axon degeneration and neuronal cell death through regulation of NAD+-biosynthetic and consuming enzymes. Cellular Signalling 108: 110717. * uses SND450 silicone devices with human iPSC-derived neurons https://doi.org/10.1016/j.cellsig.2023.110717
Tags: hiPSC-derived, human, SND450
Gatti, M., K. S. Dittlau, F. Beretti, L. Yedigaryan, M. Zavatti, P. Cortelli, C. Palumbo, E. Bertucci, L. Van Den Bosch, M. Sampaolesi and T. Maraldi, 2023. Human Neuromuscular Junction on a Chip: Impact of Amniotic Fluid Stem Cell Extracellular Vesicles on Muscle Atrophy and NMJ Integrity. International Journal of Molecular Sciences 24(5): 4944. * uses XC150 XonaChips with human-derived myotube and motor neuron co-cultures. https://doi.org/10.3390/ijms24054944
Tags: co-culture, hiPSC-derived motor neurons, human, motor neurons, myotubes, stem cells, XC150
Subramani, M., M. J. Van Hook and I. Ahmad, 2023. Reproducible generation of human retinal ganglion cells from banked retinal progenitor cells: analysis of target recognition and IGF-1-mediated axon regeneration. Front Cell Dev Biol 11: 1214104. * uses SND450 silicone devices with human RGC https://doi.org/10.3389%2Ffcell.2023.1214104
Tags: human, injury, retinal ganglion cells, SND450
Aiken, J. and E. L. F. Holzbaur, 2023. Spastin locally amplifies microtubule dynamics to pattern the axon for presynaptic cargo delivery. bioRxiv. * uses XonaChip (XC450) with human iPSC-derived i3Neurons. https://doi.org/10.1101%2F2023.08.08.552320
Tags: hiPSC-derived, human, i3Neurons, preprint, XC450
Zimyanin, V. L., A.-M. Pielka, H. Glaß, J. Japtok, D. Großmann, M. Martin, A. Deussen, B. Szewczyk, C. Deppmann, E. Zunder, P. M. Andersen, T. M. Boeckers, J. Sterneckert, S. Redemann, A. Storch and A. Hermann, 2023. Live Cell Imaging of ATP Levels Reveals Metabolic Compartmentalization within Motoneurons and Early Metabolic Changes in FUS ALS Motoneurons. Cells 12 DOI: 10.3390/cells12101352. * uses Xona's silicone devices (RD900) with human iPSC-derived motoneurons. https://doi.org/10.3390/cells12101352
Tags: hiPSC-derived motor neurons, human, RD900
Subramani, M., Hook, M.V., Rajamoorthy, M., Qiu, F., Ahmad, I., 2023. Human Retinal Ganglion Cells Respond to Evolutionarily Conserved Chemotropic Cues for Intra Retinal Guidance and Regeneration. bioRxiv, 2023.2002.2001.526677 * uses Xona’s Silicone Devices (SND450) with human retinal ganglion cells and rat retinal cells. https://doi.org/10.1101/2023.02.01.526677
Tags: human, preprint, rat, retinal ganglion cells, SND450
Lotlikar, M.S., Tarantino, M.B., Jorfi, M., Kovacs, D.M., Tanzi, R.E., Bhattacharyya, R., 2022. Microfluidic separation of axonal and somal compartments of neural progenitor cells differentiated in a 3D matrix. STAR Protocols 3, 101028. * uses XonaChips® (XC150, XC450) with human NPCs cultured in 3D using Matrigel® **PROTOCOL** https://doi.org/10.1016/j.xpro.2021.101028
Tags: 3D, human, Matrigel, NPC, protocol, XC150, XC450
Pozo Devoto, V.M., Lacovich, V., Feole, M., Bhat, P., Chovan, J., Čarna, M., Onyango, I.G., Dragišić, N., Sűsserová, M., Barrios-Llerena, M.E., Stokin, G.B., 2022. Unraveling axonal mechanisms of traumatic brain injury. Acta Neuropathologica Communications 10, 140. * uses Xona’s Silicone Devices (uLP). https://doi.org/10.1186/s40478-022-01414-8
Tags: human, injury, microfluidic local perfusion device, uLP
Pourshafie, N., Masati, E., Lopez, A., Bunker, E., Snyder, A., Edwards, N.A., Winkelsas, A.M., Fischbeck, K.H., Grunseich, C., 2022. Altered SYNJ2BP-mediated mitochondrial-ER contacts in motor neuron disease. Neurobiol Dis 172, 105832. * uses XonaChips® (XC150) with human iPSC-differentiated motor neurons. https://doi.org/10.1016/j.nbd.2022.105832
Tags: hiPSC-derived motor neurons, human, motor neuron disease, XC150
Nella, K.T., Norton, B.M., Chang, H.-T., Heuer, R.A., Roque, C.B., Matsuoka, A.J., 2022. Bridging the electrode–neuron gap: finite element modeling of in vitro neurotrophin gradients to optimize neuroelectronic interfaces in the inner ear. Acta Biomaterialia 151, 360-378. https://doi.org/10.1016/j.actbio.2022.08.035
Tags: hiPSC-derived, human, spiral ganglion neurons, XC450
Woldegebriel, R., Kvist, J., White, M., Sinkko, M., Hänninen, S., Sainio, M.T., Torregrosa-Munumer, R., Harjuhaahto, S., Huber, N., Herukka, S.-K., Haapasalo, A., Carpen, O., Bassett, A., Ylikallio, E., Sreedharan, J., Tyynismaa, H., 2021. Peripheral neuropathy linked mRNA export factor GANP reshapes gene regulation in human motor neurons. bioRxiv, * uses XonaChips® (XC450)
https://doi.org/10.1101/2021.05.18.444636
Tags: hiPSC-derived motor neurons, human, preprint, XC450
Margarita, D.C., Laura, C., Urszula, B., Amandine, G., Natalia, T.E., Isabelle, F., Hossain, I., Daniela, G., Anne, E., Matthias, M., Eline, P.-V., 2021. Mutant huntingtin actively crosses neuromuscular synapses and causes transmission-selective pathology in human myotubes. bioRxiv, 2021.2007.2028.454044. https://doi.org/10.1101/2021.07.28.454044
Tags: co-culture, hiPSC-derived, human, neuromuscular junction (NMJ), preprint, XC450
Hao, J., Wells, M.F., Niu, G., San Juan, I.G., Limone, F., Fukuda, A., Leyton-Jaimes, M.F., Joseph, B., Qian, M., Mordes, D.A., Budnik, B., Dou, Z., Eggan, K., 2021. Loss of TBK1 activity leads to TDP-43 proteinopathy through lysosomal dysfunction in human motor neurons. bioRxiv, 2021.2010.2011.464011. https://doi.org/10.1101/2021.10.11.464011
Tags: human, motor neurons, preprint, SND150
Pal, A., Kretner, B., Abo-Rady, M., Glaβ, H., Dash, B.P., Naumann, M., Japtok, J., Kreiter, N., Dhingra, A., Heutink, P., Böckers, T.M., Günther, R., Sterneckert, J., Hermann, A., 2021. Concomitant gain and loss of function pathomechanisms in C9ORF72 amyotrophic lateral sclerosis. Life Science Alliance 4, e202000764. * uses Xona’s Silicone Devices (RD900) with human iPSC-differentiated motor neurons
http://doi.org/10.26508/lsa.202000764
Tags: hiPSC-derived motor neurons, human, RD900
Bhattacharyya, R., Black, S.E., Lotlikar, M.S., Fenn, R.H., Jorfi, M., Kovacs, D.M., Tanzi, R.E., 2021. Axonal generation of amyloid-β from palmitoylated APP in mitochondria-associated endoplasmic reticulum membranes. Cell Rep 35, 109134. * uses XonaChips® (XC150, XC450) with human NPCs cultured in 3D using Matrigel® https://doi.org/10.1016/j.celrep.2021.109134
Tags: 3D, human, Matrigel, NPC, XC150, XC450
Güner, F., Pozner, T., Krach, F., Prots, I., Loskarn, S., Schlötzer-Schrehardt, U., Winkler, J., Winner, B., Regensburger, M., 2021. Axon-Specific Mitochondrial Pathology in SPG11 Alpha Motor Neurons. Frontiers in Neuroscience 15. * uses Xona’s Silicone Devices (SND450) with human iPSC-differentiated motor neuron progenitors and human cerebellar astrocytes co-cultures. https://doi.org/10.3389/fnins.2021.680572
Tags: astrocytes, co-culture, hiPSC-derived, hiPSC-derived motor neurons, human, motor neurons, SND450
van Erp, S., van Berkel, A.A., Feenstra, E.M., Sahoo, P.K., Wagstaff, L.J., Twiss, J.L., Fawcett, J.W., Eva, R., ffrench-Constant, C., 2021. Age-related loss of axonal regeneration is reflected by the level of local translation. Exp Neurol 339, 113594. * uses Xona’s Silicone Devices (RD450) with hESC-differentiated neurons. https://doi.org/10.1016/j.expneurol.2020.113594
Tags: hESC-derived, human, RD450
Stoklund Dittlau, K., Krasnow, E.N., Fumagalli, L., Vandoorne, T., Baatsen, P., Kerstens, A., Giacomazzi, G., Pavie, B., Rossaert, E., Beckers, J., Sampaolesi, M., Van Damme, P., Van Den Bosch, L., 2021. Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition. Stem Cell Reports 16, 2213-2227. * uses XonaChips® (XC150) and Xona’s Silicone Devices (SND75) with human iPSC-differentiated motor neurons and human mesoangioblasts (MAB)-derived myotubes to create in vitro NMJs.
https://doi.org/10.1016/j.stemcr.2021.03.029
Tags: hiPSC-derived motor neurons, human, neuromuscular junction (NMJ), SND75, XC150
Stoklund Dittlau, K., Krasnow, E.N., Fumagalli, L., Vandoorne, T., Baatsen, P., Kerstens, A., Giacomazzi, G., Pavie, B., Rossaert, E., Beckers, J., Sampaolesi, M., Van Damme, P., Van Den Bosch, L., 2021. Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices. JoVE, e62959. * uses XonaChips® (XC150) and Xona’s Silicone Devices (SND75) with human iPSC-differentiated motor neurons and human mesoangioblasts (MAB)-derived myotubes to create in vitro NMJs. http://doi.org/10.3791/62959
Tags: hiPSC-derived motor neurons, human, motor neurons, neuromuscular junction (NMJ), SND75, XC150
Leitão, L., Neto, E., Conceição, F., Monteiro, A., Couto, M., Alves, C.J., Sousa, D.M., Lamghari, M., 2020. Osteoblasts are inherently programmed to repel sensory innervation. Bone Research 8, 20. * uses Xona’s Silicone Devices (SND450) with mouse DRG neurons co-cultured with human mesenchymal stem cells (MSC)-differentiated osteoblasts https://doi.org/10.1038/s41413-020-0096-1
Tags: co-culture, DRG, human, mouse, osteoblasts, SND450, stem cells
Klim, J.R., Williams, L.A., Limone, F., Guerra San Juan, I., Davis-Dusenbery, B.N., Mordes, D.A., Burberry, A., Steinbaugh, M.J., Gamage, K.K., Kirchner, R., Moccia, R., Cassel, S.H., Chen, K., Wainger, B.J., Woolf, C.J., Eggan, K., 2019. ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair. Nat Neurosci. Feb;22(2):167-179. doi: 10.1038/s41593-018-0300-4. * uses Xona’s Silicone Devices (SND150) with human stem cell (iPSC and ESC) derived motor neurons https://www.ncbi.nlm.nih.gov/pubmed/30643292
Tags: human, motor neurons, SND150, stem cells
Bieri, G., Brahic, M., Bousset, L., Couthouis, J., Kramer, N.J., Ma, R., Nakayama, L., Monbureau, M., Defensor, E., Schüle, B., Shamloo, M., Melki, R., Gitler, A.D., 2019. LRRK2 modifies α-syn pathology and spread in mouse models and human neurons. Acta Neuropathol. 2019 Mar 29. doi: 10.1007/s00401-019-01995-0. * uses Xona’s Silicone Devices (SND450) with human stem cell derived neurons https://www.ncbi.nlm.nih.gov/pubmed/30927072
Tags: human, SND450, stem cells
Kamande, J.W., Nagendran, T., Harris, J., Taylor, A.M., 2019. Multi-compartment Microfluidic Device Geometry and Covalently Bound Poly-D-Lysine Influence Neuronal Maturation. Front. Bioeng. Biotechnol. | doi: 10.3389/fbioe.2019.00084. * uses Xona’s Silicone Devices (SND450, DOC450) with human stem cell derived glutamatergic neurons **Original research authored by Xona scientists** https://www.frontiersin.org/articles/10.3389/fbioe.2019.00084/abstract
Tags: DOC450, glutamatergic, hiPSC-derived, human, SND450, Xona author
Paranjape, S. R., Nagendran, T., Poole, V., Harris, J., Taylor, A. M. (2019). Compartmentalization of Human Stem Cell-Derived Neurons within Pre-Assembled Plastic Microfluidic Chips J. Vis. Exp. (147), e59250, doi:10.3791/59250 (2019). * uses XonaChips® (XC150, XC450, XC900) with human stem cell derived glutamatergic neurons **authored by Xona scientists https://www.jove.com/video/59250/compartmentalization-human-stem-cell-derived-neurons-within-pre?status=a61256k
Tags: glutamatergic, hiPSC-derived, human, protocol, XC150, XC450, XC900, Xona author
Hixon, A. M., Clarke, P., & Tyler, K. L. (2019). Contemporary Circulating Enterovirus D68 Strains Infect and Undergo Retrograde Axonal Transport in Spinal Motor Neurons Independent of Sialic Acid. Journal of virology, 93(16), e00578-19. https://doi.org/10.1128/JVI.00578-19 * uses Xona’s Silicone Devices (RD450) with human iPSC-derived motor neurons https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675884/
Tags: hiPSC-derived motor neurons, human, RD450
Nijssen, J., Aguila, J. and Hedlund, E. (2019). Axon-seq for in Depth Analysis of the RNA Content of Neuronal Processes. Bio-protocol 9(14): e3312. DOI: 10.21769/BioProtoc.3312. * uses Xona’s Silicone Devices (SND150, SND450, SND900) with mouse and human stem cell derived motor neurons https://bio-protocol.org/e3312
Tags: human, motor neurons, mouse, protocol, SND150, SND450, SND900, stem cells
Teotia, P., Van Hook, M.J., Fischer, D., Ahmad, I., 2019. Human retinal ganglion cell axon regeneration by recapitulating developmental mechanisms: effects of recruitment of the mTOR pathway. Development 146, dev178012. * uses Xona’s Silicone Devices (SND450) with human retinal ganglion cells
https://doi.org/10.1242/dev.178012
Tags: human, retinal ganglion cells, SND450
Nijssen, J., Aguila, J., Hoogstraaten, R., Kee, N., Hedlund, E., 2018. Axon-Seq Decodes the Motor Axon Transcriptome and Its Modulation in Response to ALS. Stem Cell Reports 11, 1565-1578. * uses SND150 silicone devices with human motor neurons. https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(18)30473-9
Tags: ALS, human, motor neurons, SND150
Naumann, M., Pal, A., Goswami, A., Lojewski, X., Japtok, J., Vehlow, A., Naujock, M., Günther, R., Jin, M., Stanslowsky, N., Reinhardt, P., Sterneckert, J., Frickenhaus, M., Pan-Montojo, F., Storkebaum, E., Poser, I., Freischmidt, A., Weishaupt, J.H., Holzmann, K., Troost, D., Ludolph, A.C., Boeckers, T.M., Liebau, S., Petri, S., Cordes, N., Hyman, A.A., Wegner, F., Grill, S.W., Weis, J., Storch, A., Hermann, A., 2018. Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation. Nature Communications 9, 335. * uses Xona’s Silicone Devices (RD900) with human iPSC-differentiated motor neurons https://doi.org/10.1038/s41467-017-02299-1
Tags: hiPSC-derived motor neurons, human, RD900