Gatti, M., K. S. Dittlau, F. Beretti, L. Yedigaryan, M. Zavatti, P. Cortelli, C. Palumbo, E. Bertucci, L. Van Den Bosch, M. Sampaolesi and T. Maraldi, 2023. Human Neuromuscular Junction on a Chip: Impact of Amniotic Fluid Stem Cell Extracellular Vesicles on Muscle Atrophy and NMJ Integrity. International Journal of Molecular Sciences 24(5): 4944. * uses XC150 XonaChips with human-derived myotube and motor neuron co-cultures. https://doi.org/10.3390/ijms24054944
Tags: co-culture, hiPSC-derived motor neurons, human, motor neurons, myotubes, stem cells, XC150
Kandhavivorn, W., H. Glaß, T. Herrmannsdörfer, T. M. Böckers, M. Uhlarz, J. Gronemann, R. H. W. Funk, J. Pietzsch, A. Pal and A. Hermann, 2023. Restoring Axonal Organelle Motility and Regeneration in Cultured FUS-ALS Motoneurons through Magnetic Field Stimulation Suggests an Alternative Therapeutic Approach. Cells 12 DOI: 10.3390/cells12111502. * uses Xona's silicone devices (RD900) with hiPSC-derived motor neurons. https://doi.org/10.3390/cells12111502
Tags: hiPSC-derived motor neurons, RD900
Zimyanin, V. L., A.-M. Pielka, H. Glaß, J. Japtok, D. Großmann, M. Martin, A. Deussen, B. Szewczyk, C. Deppmann, E. Zunder, P. M. Andersen, T. M. Boeckers, J. Sterneckert, S. Redemann, A. Storch and A. Hermann, 2023. Live Cell Imaging of ATP Levels Reveals Metabolic Compartmentalization within Motoneurons and Early Metabolic Changes in FUS ALS Motoneurons. Cells 12 DOI: 10.3390/cells12101352. * uses Xona's silicone devices (RD900) with human iPSC-derived motoneurons. https://doi.org/10.3390/cells12101352
Tags: hiPSC-derived motor neurons, human, RD900
Stoklund Dittlau, K., Terrie, L., Baatsen, P., Kerstens, A., De Swert, L., Janky, R.s., Corthout, N., Masrori, P., Van Damme, P., Hyttel, P., Meyer, M., Thorrez, L., Freude, K., Van Den Bosch, L., 2023. FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms. Molecular Neurodegeneration 18, 5. * uses XonaChips® (XC150) with co-culture of hiPSC-derived motor neurons and astrocytes with human primary myoblasts. https://doi.org/10.1186/s13024-022-00591-3
Tags: astrocytes, co-culture, hiPSC-derived motor neurons, myoblasts, XC150
Limone, F., Guerra San Juan, I., Mitchell, J.M., Smith, J.L.M., Raghunathan, K., Meyer, D., Ghosh, S.D., Couto, A., Klim, J.R., Joseph, B.J., Gold, J., Mello, C.J., Nemesh, J., Smith, B.M., Verhage, M., McCarroll, S.A., Pietiläinen, O., Nehme, R., Eggan, K., 2023. Efficient generation of lower induced motor neurons by coupling Ngn2 expression with developmental cues. Cell Reports 42, 111896.
* uses XonaChips® (XC450) with co-culture of human lower induced motor neurons (liMNs) and primary murine myoblasts. https://doi.org/10.1016/j.celrep.2022.111896
Tags: co-culture, hiPSC-derived motor neurons, myoblasts, XC450
Günther, R., Pal, A., Williams, C., Zimyanin, V.L., Liehr, M., von Neubeck, C., Krause, M., Parab, M.G., Petri, S., Kalmbach, N., Marklund, S.L., Sterneckert, J., Munch Andersen, P., Wegner, F., Gilthorpe, J.D., Hermann, A., 2022. Alteration of Mitochondrial Integrity as Upstream Event in the Pathophysiology of SOD1-ALS, Cells. * uses Xona’s Silicone Devices (RD900) with hiPSC-derived motor neurons. https://doi.org/10.3390/cells11071246
Tags: ALS, hiPSC-derived motor neurons, RD900
Costamagna, D., Casters, V., Beltrà, M., Sampaolesi, M., Van Campenhout, A., Ortibus, E., Desloovere, K., Duelen, R., 2022. Autologous iPSC-Derived Human Neuromuscular Junction to Model the Pathophysiology of Hereditary Spastic Paraplegia, Cells. * uses XonaChips® (XC150) with human iPSC-differentiated lower motor neurons and myoblasts to create in vitro NMJs. https://doi.org/10.3390/cells11213351
Tags: hereditary spastic paraplegia, hiPSC-derived motor neurons, lower motor neurons, myoblasts, neuromuscular junction (NMJ), XC150
Pourshafie, N., Masati, E., Lopez, A., Bunker, E., Snyder, A., Edwards, N.A., Winkelsas, A.M., Fischbeck, K.H., Grunseich, C., 2022. Altered SYNJ2BP-mediated mitochondrial-ER contacts in motor neuron disease. Neurobiol Dis 172, 105832. * uses XonaChips® (XC150) with human iPSC-differentiated motor neurons. https://doi.org/10.1016/j.nbd.2022.105832
Tags: hiPSC-derived motor neurons, human, motor neuron disease, XC150
Woldegebriel, R., Kvist, J., White, M., Sinkko, M., Hänninen, S., Sainio, M.T., Torregrosa-Munumer, R., Harjuhaahto, S., Huber, N., Herukka, S.-K., Haapasalo, A., Carpen, O., Bassett, A., Ylikallio, E., Sreedharan, J., Tyynismaa, H., 2021. Peripheral neuropathy linked mRNA export factor GANP reshapes gene regulation in human motor neurons. bioRxiv, * uses XonaChips® (XC450)
https://doi.org/10.1101/2021.05.18.444636
Tags: hiPSC-derived motor neurons, human, preprint, XC450
Pal, A., Kretner, B., Abo-Rady, M., Glaβ, H., Dash, B.P., Naumann, M., Japtok, J., Kreiter, N., Dhingra, A., Heutink, P., Böckers, T.M., Günther, R., Sterneckert, J., Hermann, A., 2021. Concomitant gain and loss of function pathomechanisms in C9ORF72 amyotrophic lateral sclerosis. Life Science Alliance 4, e202000764. * uses Xona’s Silicone Devices (RD900) with human iPSC-differentiated motor neurons
http://doi.org/10.26508/lsa.202000764
Tags: hiPSC-derived motor neurons, human, RD900
Güner, F., Pozner, T., Krach, F., Prots, I., Loskarn, S., Schlötzer-Schrehardt, U., Winkler, J., Winner, B., Regensburger, M., 2021. Axon-Specific Mitochondrial Pathology in SPG11 Alpha Motor Neurons. Frontiers in Neuroscience 15. * uses Xona’s Silicone Devices (SND450) with human iPSC-differentiated motor neuron progenitors and human cerebellar astrocytes co-cultures. https://doi.org/10.3389/fnins.2021.680572
Tags: astrocytes, co-culture, hiPSC-derived, hiPSC-derived motor neurons, human, motor neurons, SND450
Stoklund Dittlau, K., Krasnow, E.N., Fumagalli, L., Vandoorne, T., Baatsen, P., Kerstens, A., Giacomazzi, G., Pavie, B., Rossaert, E., Beckers, J., Sampaolesi, M., Van Damme, P., Van Den Bosch, L., 2021. Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition. Stem Cell Reports 16, 2213-2227. * uses XonaChips® (XC150) and Xona’s Silicone Devices (SND75) with human iPSC-differentiated motor neurons and human mesoangioblasts (MAB)-derived myotubes to create in vitro NMJs.
https://doi.org/10.1016/j.stemcr.2021.03.029
Tags: hiPSC-derived motor neurons, human, neuromuscular junction (NMJ), SND75, XC150
Stoklund Dittlau, K., Krasnow, E.N., Fumagalli, L., Vandoorne, T., Baatsen, P., Kerstens, A., Giacomazzi, G., Pavie, B., Rossaert, E., Beckers, J., Sampaolesi, M., Van Damme, P., Van Den Bosch, L., 2021. Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices. JoVE, e62959. * uses XonaChips® (XC150) and Xona’s Silicone Devices (SND75) with human iPSC-differentiated motor neurons and human mesoangioblasts (MAB)-derived myotubes to create in vitro NMJs. http://doi.org/10.3791/62959
Tags: hiPSC-derived motor neurons, human, motor neurons, neuromuscular junction (NMJ), SND75, XC150
Abo-Rady, M., Kalmbach, N., Pal, A., Schludi, C., Janosch, A., Richter, T., Freitag, P., Bickle, M., Kahlert, A.K., Petri, S., Stefanov, S., Glass, H., Staege, S., Just, W., Bhatnagar, R., Edbauer, D., Hermann, A., Wegner, F., Sterneckert, J.L., 2020. Knocking out C9ORF72 Exacerbates Axonal Trafficking Defects Associated with Hexanucleotide Repeat Expansion and Reduces Levels of Heat Shock Proteins. Stem Cell Reports 14, 390-405. * uses Xona’s Silicone Devices with human iPSC-differentiated motor neurons https://doi.org/10.1016%2Fj.stemcr.2020.01.010
Tags: hiPSC-derived motor neurons, SND450
Hixon, A. M., Clarke, P., & Tyler, K. L. (2019). Contemporary Circulating Enterovirus D68 Strains Infect and Undergo Retrograde Axonal Transport in Spinal Motor Neurons Independent of Sialic Acid. Journal of virology, 93(16), e00578-19. https://doi.org/10.1128/JVI.00578-19 * uses Xona’s Silicone Devices (RD450) with human iPSC-derived motor neurons https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675884/
Tags: hiPSC-derived motor neurons, human, RD450
Naumann, M., Pal, A., Goswami, A., Lojewski, X., Japtok, J., Vehlow, A., Naujock, M., Günther, R., Jin, M., Stanslowsky, N., Reinhardt, P., Sterneckert, J., Frickenhaus, M., Pan-Montojo, F., Storkebaum, E., Poser, I., Freischmidt, A., Weishaupt, J.H., Holzmann, K., Troost, D., Ludolph, A.C., Boeckers, T.M., Liebau, S., Petri, S., Cordes, N., Hyman, A.A., Wegner, F., Grill, S.W., Weis, J., Storch, A., Hermann, A., 2018. Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation. Nature Communications 9, 335. * uses Xona’s Silicone Devices (RD900) with human iPSC-differentiated motor neurons https://doi.org/10.1038/s41467-017-02299-1
Tags: hiPSC-derived motor neurons, human, RD900