Paper Highlight! The Van Den Bosch Lab (KU Leuven/VIB) creates in vitro human motor units using XonaChips®. These results were recently published in Stem Cell Reports April 2021. iPSCs were differentiated into motor neurons in one compartment and mesoangioblast-derived myotubes in the other. A gradient of neurotrophic factors was used to direct the axons of spinal motor neurons through the microgrooves to form NMJs with the myotubes. The authors show that using ALS model neurons to re-create NMJs within compartmentalized chips leads to quantifiable defects mirroring disease phenotypes. Learn about XonaChips® and this article: https://doi.org/10.1016/j.stemcr.2021.03.029
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