Salehi, S., A. Zare, G. Prezza, J. Bader, C. Schneider, U. Fischer, F. Meissner, M. Mann, M. Briese and M. Sendtner, 2023. Cytosolic Ptbp2 modulates axon growth in motoneurons through axonal localization and translation of Hnrnpr. Nature Communications 14(1): 4158. * uses IND150 and RD150 silicone devices with mouse motoneurons. https://doi.org/10.1038/s41467-023-39787-6
Tags: IND150, motor neurons, mouse, primary, RD450
Murata, H., Y. Yasui, K. Oiso, T. Ochi, N. Tomonobu, K.-i. Yamamoto, R. Kinoshita and M. Sakaguchi, 2023. STAT1/3 signaling suppresses axon degeneration and neuronal cell death through regulation of NAD+-biosynthetic and consuming enzymes. Cellular Signalling 108: 110717. * uses SND450 silicone devices with human iPSC-derived neurons https://doi.org/10.1016/j.cellsig.2023.110717
Tags: hiPSC-derived, human, SND450
Gatti, M., K. S. Dittlau, F. Beretti, L. Yedigaryan, M. Zavatti, P. Cortelli, C. Palumbo, E. Bertucci, L. Van Den Bosch, M. Sampaolesi and T. Maraldi, 2023. Human Neuromuscular Junction on a Chip: Impact of Amniotic Fluid Stem Cell Extracellular Vesicles on Muscle Atrophy and NMJ Integrity. International Journal of Molecular Sciences 24(5): 4944. * uses XC150 XonaChips with human-derived myotube and motor neuron co-cultures. https://doi.org/10.3390/ijms24054944
Tags: co-culture, hiPSC-derived motor neurons, human, motor neurons, myotubes, stem cells, XC150
Subramani, M., M. J. Van Hook and I. Ahmad, 2023. Reproducible generation of human retinal ganglion cells from banked retinal progenitor cells: analysis of target recognition and IGF-1-mediated axon regeneration. Front Cell Dev Biol 11: 1214104. * uses SND450 silicone devices with human RGC https://doi.org/10.3389%2Ffcell.2023.1214104
Tags: human, injury, retinal ganglion cells, SND450
Baker, C. A., S. Tyagi, G. P. Higerd-Rusli, S. Liu, P. Zhao, F. B. Dib-Hajj, S. G. Waxman and S. D. Dib-Hajj, 2023. Paclitaxel effects on axonal localization and vesicular trafficking of NaV1.8. Frontiers in Molecular Neuroscience 16. * Uses SND450 silicone devices with rat DRG neurons. https://doi.org/10.3389/fnmol.2023.1130123
Tags: DRG, rat, SND450
Siddiq, M. M., C. A. Toro, N. P. Johnson, J. Hansen, Y. Xiong, W. Mellado, R. E. Tolentino, K. Johnson, G. Jayaraman, Z. Suhail, L. Harlow, J. Dai, K. G. Beaumont, R. Sebra, D. E. Willis, C. P. Cardozo and R. Iyengar, 2023. Spinal cord injury regulates circular RNA expression in axons. Front Mol Neurosci 16: 1183315. * uses Xona's silicone devices (SND450) with primary cortical neurons https://doi.org/10.3389%2Ffnmol.2023.1183315
Tags: cortical neurons, injury, mouse, primary, rat, SND450
Kandhavivorn, W., H. Glaß, T. Herrmannsdörfer, T. M. Böckers, M. Uhlarz, J. Gronemann, R. H. W. Funk, J. Pietzsch, A. Pal and A. Hermann, 2023. Restoring Axonal Organelle Motility and Regeneration in Cultured FUS-ALS Motoneurons through Magnetic Field Stimulation Suggests an Alternative Therapeutic Approach. Cells 12 DOI: 10.3390/cells12111502. * uses Xona's silicone devices (RD900) with hiPSC-derived motor neurons. https://doi.org/10.3390/cells12111502
Tags: hiPSC-derived motor neurons, RD900
Chan, C., K. Ramhari, W. Hu, Y. Xiuli, G. Kundlik, R. Cyrus, K. Yasuyoshi, B. Adam, K. Sruthi, J. Deok, W. Liang, W. Anthony, C. Rong, Z. Shu, J. Lingtao, J. W. Creg, A. A. V. Dario, P. Olga, W. N. David, C. W. Philip, C. T. Juan, Y. Mingyao, L. D. Valina, M. D. Ted and M. Xiaobo, 2023. Pathological Tau transmission initiated by binding lymphocyte-activation gene 3. bioRxiv: 2023.2005.2016.541015. * uses Xona's silicone devices (TCND1000) with primary mouse cortical neurons. https://doi.org/10.1101/2023.05.16.541015
Tags: cortical neurons, mouse, preprint, primary, TCND1000
Clara, M., V. F. Shaline, S. Nathalie, L. Andrea, P. C. Michael and A.-F. Peter, 2023. Distinct axo-protective and axo-destructive roles for Schwann cells after injury in a novel compartmentalised mouse myelinating coculture system. bioRxiv: 2023.2005.2019.541371. * uses Xona's silicone devices (SND150) with mouse primary co-cultures of DRG and myelinating Schwann cells. https://doi.org/10.1101/2023.05.19.541371
Tags: co-culture, DRG, mouse, myelination, preprint, primary, Schwann cells, SND150
Alessandra, P., C. Laura, L. Fabio, M. Chiara, S. Elisa, A. Alessandro, P. Paola, M. Marta, C. Filippo, C. Ottavio, T. Stefano, Q. Angelo, C. Jean-Michel, V. Gabriella, C. Franca and G. G. Consalez, 2023. Two neuronal models of TDP-43 proteinopathy display reduced axonal translation, increased oxidative stress, and defective exocytosis. bioRxiv: 2023.2005.2017.540919. * uses Xona's silicone devices (SND450) with mouse cortical neurons. https://doi.org/10.1101/2023.05.17.540919
Tags: cortical neurons, mouse, preprint, primary, SND450
Aiken, J. and E. L. F. Holzbaur, 2023. Spastin locally amplifies microtubule dynamics to pattern the axon for presynaptic cargo delivery. bioRxiv. * uses XonaChip (XC450) with human iPSC-derived i3Neurons. https://doi.org/10.1101%2F2023.08.08.552320
Tags: hiPSC-derived, human, i3Neurons, preprint, XC450
Zimyanin, V. L., A.-M. Pielka, H. Glaß, J. Japtok, D. Großmann, M. Martin, A. Deussen, B. Szewczyk, C. Deppmann, E. Zunder, P. M. Andersen, T. M. Boeckers, J. Sterneckert, S. Redemann, A. Storch and A. Hermann, 2023. Live Cell Imaging of ATP Levels Reveals Metabolic Compartmentalization within Motoneurons and Early Metabolic Changes in FUS ALS Motoneurons. Cells 12 DOI: 10.3390/cells12101352. * uses Xona's silicone devices (RD900) with human iPSC-derived motoneurons. https://doi.org/10.3390/cells12101352
Tags: hiPSC-derived motor neurons, human, RD900
Cai, X., M. Han, F. Lou, Y. Sun, Q. Yin, L. Sun, Z. Wang, X. Li, H. Zhou, Z. Xu, H. Wang, S. Deng, X. Zheng, T. Zhang, Q. Li, B. Zhou and H. Wang, 2023. Tenascin C+ papillary fibroblasts facilitate neuro-immune interaction in a mouse model of psoriasis. Nature Communications 14(1): 2004. * uses XonaChips (XC150) with mouse DRG co-cultures. https://doi.org/10.1038/s41467-023-37798-x
Tags: co-culture, DRG, mouse, primary, XC150
Salas-Lucia, F., C. Fekete, R. Sinkó, P. Egri, K. Rada, Y. Ruska, B. Gereben and A. C. Bianco, 2023. Axonal T3 uptake and transport can trigger thyroid hormone signaling in the brain. eLife 12: e82683. * uses XonaChips (XC450) with primary mouse cortical neurons. https://doi.org/10.7554/eLife.82683
Tags: cortical neurons, mouse, primary, XC450
, , , , , , , , , , Low Forces Push the Maturation of Neural Precursors into Neurons. Small 2023, 2205871. * uses Xona’s Silicone Devices (RD150) with hiPSC-differentiated spinal cord neurons. http://doi.org/10.1002/smll.202205871
Tags: hiPSC-derived, RD150, spinal cord neurons
Neel DV, Basu H, Gunner G, Bergstresser MD, Giadone RM, Chung H, Miao R, Chou V, Brody E, Jiang X, Lee E, Watts ME, Marques C, Held A, Wainger B, Lagier-Tourenne C, Zhang YJ, Petrucelli L, Young-Pearse TL, Chen-Plotkin AS, Rubin LL, Lieberman J, Chiu IM. Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration. Neuron. 2023 Apr 19;111(8):1222-1240.e9. * uses XonaChips® (XC450) and Xona’s Silicone Devices (RD450) using mouse cortical neurons. http://doi.org/10.1016/j.neuron.2023.02.019
Tags: cortical neurons, mouse, RD450, XC450
Xu, X., Zhang, H., Li, J., Chen, Y., Zhong, W., Chen, Y., Ma, X., 2023. Combination of EPC-EXs and NPC-EXs with miR-126 and miR-210 overexpression produces better therapeutic effects on ischemic stroke by protecting neurons through the Nox2/ROS and BDNF/TrkB pathways. Exp Neurol 359, 114235. https://doi.org/10.1016/j.expneurol.2022.114235
Kaniyappan, S., Balaji, V., Wang, Y., Mandelkow, E., 2023. Microfluidic Chamber Technology to Study Missorting and Spreading of Tau Protein in Alzheimer’s Disease, in: Cieplak, A.S. (Ed.), Protein Aggregation: Methods and Protocols. New York, NY: Springer US, pp. 111-123. * uses Xona’s Silicone (PDMS) Devices (RD150, TCND1000) with primary rat cortical or hippocampal neurons **PROTOCOL** https://doi.org/10.1007/978-1-0716-2597-2_9
Tags: cortical neurons, hippocampal neurons, primary, protocol, rat, RD150, TCND1000
Higerd-Rusli, G.P., Tyagi, S., Baker, C.A., Liu, S., Dib-Hajj, F.B., Dib-Hajj, S.D., Waxman, S.G., 2023. Inflammation differentially controls transport of depolarizing Nav versus hyperpolarizing Kv channels to drive rat nociceptor activity. Proceedings of the National Academy of Sciences 120, e2215417120. https://www.pnas.org/doi/10.1073/pnas.2215417120
Tags: basic research, DOC450, postnatal, rat
Stoklund Dittlau, K., Terrie, L., Baatsen, P., Kerstens, A., De Swert, L., Janky, R.s., Corthout, N., Masrori, P., Van Damme, P., Hyttel, P., Meyer, M., Thorrez, L., Freude, K., Van Den Bosch, L., 2023. FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms. Molecular Neurodegeneration 18, 5. * uses XonaChips® (XC150) with co-culture of hiPSC-derived motor neurons and astrocytes with human primary myoblasts. https://doi.org/10.1186/s13024-022-00591-3
Tags: astrocytes, co-culture, hiPSC-derived motor neurons, myoblasts, XC150
Yang, X., Tohda, C., 2023. Axonal Regeneration Mediated by a Novel Axonal Guidance Pair, Galectin-1 and Secernin-1. Mol Neurobiol 60, 1250-1266. https://doi.org/10.1007/s12035-022-03125-6
Tags: hippocampal neurons, primary
Falconieri, A., De Vincentiis, S., Cappello, V., Convertino, D., Das, R., Ghignoli, S., Figoli, S., Luin, S., Català-Castro, F., Marchetti, L., Borello, U., Krieg, M., Raffa, V., 2023. Axonal plasticity in response to active forces generated through magnetic nano-pulling. Cell Reports 42, 111912. * uses Xona’s Silicone Devices (RD150) with primary mouse hippocampal and DRG neurons. https://doi.org/10.1016/j.celrep.2022.111912
Tags: DRG, hippocampal neurons, mouse, RD150
Hennlein, L., Ghanawi, H., Gerstner, F., Palominos García, E., Yildirim, E., Saal-Bauernschubert, L., Moradi, M., Deng, C., Klein, T., Appenzeller, S., Sauer, M., Briese, M., Simon, C., Sendtner, M., Jablonka, S., 2023. Plastin 3 rescues cell surface translocation and activation of TrkB in spinal muscular atrophy. Journal of Cell Biology 222, e202204113. https://doi.org/10.1083/jcb.202204113
Tags: motor neurons, mouse, primary, SND150, spinal muscular atrophy
Vevea, J.D., Chapman, E.R., 2023. Mitofusin 2 sustains the axonal mitochondrial network to support presynaptic Ca2+ homeostasis and the synaptic vesicle cycle in rat hippocampal axons. The Journal of Neuroscience, JN-RM-1356-1322. https://doi.org/10.1523/JNEUROSCI.1356-22.2023
Tags: basic research, hippocampal neurons, rat
Limone, F., Guerra San Juan, I., Mitchell, J.M., Smith, J.L.M., Raghunathan, K., Meyer, D., Ghosh, S.D., Couto, A., Klim, J.R., Joseph, B.J., Gold, J., Mello, C.J., Nemesh, J., Smith, B.M., Verhage, M., McCarroll, S.A., Pietiläinen, O., Nehme, R., Eggan, K., 2023. Efficient generation of lower induced motor neurons by coupling Ngn2 expression with developmental cues. Cell Reports 42, 111896.
* uses XonaChips® (XC450) with co-culture of human lower induced motor neurons (liMNs) and primary murine myoblasts. https://doi.org/10.1016/j.celrep.2022.111896
Tags: co-culture, hiPSC-derived motor neurons, myoblasts, XC450
Higerd-Rusli, G.P., Tyagi, S., Liu, S., Dib-Hajj, F.B., Waxman, S.G., Dib-Hajj, S.D., 2023. The fates of internalized NaV1.7 channels in sensory neurons: Retrograde cotransport with other ion channels, axon-specific recycling, and degradation. Journal of Biological Chemistry 299 * uses Xona’s Silicone Devices (DOC450) with primary rat DRGs (P2-4). https://doi.org/10.1016/j.jbc.2022.102816
Tags: basic research, DOC450, postnatal, rat
Antoniou, A., Auderset, L., Kaurani, L., Sebastian, E., Zeng, Y., Allahham, M., Cases-Cunillera, S., Schoch, S., Gründemann, J., Fischer, A., Schneider, A., 2023. Neuronal extracellular vesicles and associated microRNAs induce circuit connectivity downstream BDNF. Cell Reports 42 * uses XonaChips® (XC150) and Silicone Devices (TCND500) with mouse cortical and hippocampal neurons (E16). https://doi.org/10.1016/j.celrep.2023.112063
Tags: cortical neurons, hippocampal neurons, mouse, TCND500, XC150
Antoniou, A., Auderset, L., Kaurani, L., Sebastian, E., Zeng, Y., Allahham, M., Cases-Cunillera, S., Schoch, S., Gründemann, J., Fischer, A., Schneider, A., 2023. Neuronal extracellular vesicles and associated microRNAs induce circuit connectivity downstream...
Hanč, P., Gonzalez, R.J., Mazo, I.B., Wang, Y., Lambert, T., Ortiz, G., Miller, E.W., von Andrian, U.H., Multimodal control of dendritic cell functions by nociceptors. Science 379, eabm5658. * co-culture of nociceptors and dendritic cells. 10.1126/science.abm5658
Tags: co-culture, dendritic cells, mouse, nociceptors, pain
Hanč, P., Gonzalez, R.J., Mazo, I.B., Wang, Y., Lambert, T., Ortiz, G., Miller, E.W., von Andrian, U.H., Multimodal control of dendritic cell functions by nociceptors. Science 379, eabm5658. * co-culture of nociceptors and dendritic cells.
Subramani, M., Hook, M.V., Rajamoorthy, M., Qiu, F., Ahmad, I., 2023. Human Retinal Ganglion Cells Respond to Evolutionarily Conserved Chemotropic Cues for Intra Retinal Guidance and Regeneration. bioRxiv, 2023.2002.2001.526677 * uses Xona’s Silicone Devices (SND450) with human retinal ganglion cells and rat retinal cells. https://doi.org/10.1101/2023.02.01.526677
Tags: human, preprint, rat, retinal ganglion cells, SND450