Loreto, A., Angeletti, C., Gu, W., Osborne, A., Nieuwenhuis, B., Gilley, J., Arthur-Farraj, P., Merlini, E., Amici, A., Luo, Z., Hartley-Tassell, L., Ve, T., Desrochers, L.M., Wang, Q., Kobe, B., Orsomando, G., Coleman, M.P., 2021. Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1. eLife, https://doi.org/10.7554/eLife.72823
Woldegebriel, R., Kvist, J., White, M., Sinkko, M., Hänninen, S., Sainio, M.T., Torregrosa-Munumer, R., Harjuhaahto, S., Huber, N., Herukka, S.-K., Haapasalo, A., Carpen, O., Bassett, A., Ylikallio, E., Sreedharan, J., Tyynismaa, H., 2021. Peripheral neuropathy linked mRNA export factor GANP reshapes gene regulation in human motor neurons. bioRxiv, * uses XonaChips® (XC450)
https://doi.org/10.1101/2021.05.18.444636
Tags: hiPSC-derived motor neurons, human, preprint, XC450
Mao, X., Gu, H., Kim, D., Kimura, Y., Wang, N., Xu, E., Wang, H., Chen, C., Zhang, S., Jia, C., Liu, Y., Bian, H., Karuppagounder, S.S., Jia, L., Ke, X., Chang, M., Li, A., Yang, J., Rastegar, C., Sriparna, M., Ge, P., Brahmachari, S., Kim, S., Zhang, S., Shimoda, Y., Saar, M., Workman, C.J., Vignali, D.A.A., Muller, U.C., Liu, C., Ko, H.S., Dawson, V.L., Dawson, T.M., 2021. Aplp1 and the Aplp1-Lag3 Complex facilitates transmission of pathologic α-synuclein. bioRxiv, 2021.2005.2001.442157. https://doi.org/10.1101/2021.05.01.442157
Tags: cortical neurons, mouse, preprint, TCND1000
Margarita, D.C., Laura, C., Urszula, B., Amandine, G., Natalia, T.E., Isabelle, F., Hossain, I., Daniela, G., Anne, E., Matthias, M., Eline, P.-V., 2021. Mutant huntingtin actively crosses neuromuscular synapses and causes transmission-selective pathology in human myotubes. bioRxiv, 2021.2007.2028.454044. https://doi.org/10.1101/2021.07.28.454044
Tags: co-culture, hiPSC-derived, human, neuromuscular junction (NMJ), preprint, XC450
Hao, J., Wells, M.F., Niu, G., San Juan, I.G., Limone, F., Fukuda, A., Leyton-Jaimes, M.F., Joseph, B., Qian, M., Mordes, D.A., Budnik, B., Dou, Z., Eggan, K., 2021. Loss of TBK1 activity leads to TDP-43 proteinopathy through lysosomal dysfunction in human motor neurons. bioRxiv, 2021.2010.2011.464011. https://doi.org/10.1101/2021.10.11.464011
Tags: human, motor neurons, preprint, SND150
Lee, S., Park, D., Lim, C., Kim, J.-I., Min, K.-T., 2021. Local protein synthesis of mtIF3 regulates mitochondrial translation for axonal development. bioRxiv, 2021.2001.2026.428248. * uses Xona’s Silicone Devices (RD150) with mouse hippocampal neurons https://doi.org/10.1101/2021.01.26.428248
Tags: hippocampal neurons, mouse, preprint, RD150
Bindas, A.J., Kulkarni, S., Koppes, R.A., Koppes, A.N., 2021. Parkinson’s disease and the gut: Models of an emerging relationship. Acta Biomaterialia 132, 325-344. Review http://doi.org/10.1016/j.actbio.2021.03.071
Atmaramani, R., Veeramachaneni, S., Mogas, L.V., Koppikar, P., Black, B.J., Hammack, A., Pancrazio, J.J., Granja-Vazquez, R., 2021. Investigating the Function of Adult DRG Neuron Axons Using an In Vitro Microfluidic Culture System. Micromachines 12. * uses Xona’s Silicone Devices (SND150) http://doi.org/10.3390/mi12111317
Tags: SND150
Prox, J., Seicol, B., Qi, H., Argall, A., Araya, N., Behnke, N., Guo, L., 2021. Toward living neuroprosthetics: developing a biological brain pacemaker as a living neuromodulatory implant for improving parkinsonian symptoms. Journal of Neural Engineering 18, 046081. http://doi.org/10.1088/1741-2552/ac02dd
Ha, T.-Y., Choi, Y.R., Noh, H.R., Cha, S.-H., Kim, J.-B., Park, S.M., 2021. Age-related increase in caveolin-1 expression facilitates cell-to-cell transmission of α-synuclein in neurons. Molecular Brain 14, 122. * uses Xona’s Silicone Devices (TCND1000) with mouse cortical neurons and compartmentalized α-syn fibrils
https://doi.org/10.1186/s13041-021-00834-2
Tags: cortical neurons, mouse, TCND1000
Siddiq, M.M., Hannila, S.S., Zorina, Y., Nikulina, E., Rabinovich, V., Hou, J., Huq, R., Richman, E.L., Tolentino, R.E., Hansen, J., Velenosi, A., Kwon, B.K., Tsirka, S.E., Maze, I., Sebra, R., Beaumont, K.G., Toro, C.A., Cardozo, C.P., Iyengar, R., Filbin, M.T., 2021. Extracellular histones, a new class of inhibitory molecules of CNS axonal regeneration. Brain Communications, fcab271.* uses Xona’s Silicone Devices (SND150, SND450) with rat DRG neurons http://doi.org/10.1093/braincomms/fcab271
Tags: DRG, rat, SND150, SND450
Cai, E., Cheng, Q., Yu, S., Ding, F., 2021. Achyranthes bidentata polypeptide k enhances the survival, growth and axonal regeneration of spinal cord motor neurons in vitro. NeuroReport 32. http://doi.org/10.1097/WNR.0000000000001621
Dauer née Joppe, K., Tatenhorst, L., Caldi Gomes, L., Zhang, S., Parvaz, M., Carboni, E., Roser, A.-E., El DeBakey, H., Bähr, M., Vogel-Mikuš, K., Wang Ip, C., Becker, S., Zweckstetter, M., Lingor, P., 2021. Brain iron enrichment attenuates α-synuclein spreading after injection of preformed fibrils. J Neurochem 159, 554-573. http://doi.org/10.1111/jnc.15461
Pal, A., Kretner, B., Abo-Rady, M., Glaβ, H., Dash, B.P., Naumann, M., Japtok, J., Kreiter, N., Dhingra, A., Heutink, P., Böckers, T.M., Günther, R., Sterneckert, J., Hermann, A., 2021. Concomitant gain and loss of function pathomechanisms in C9ORF72 amyotrophic lateral sclerosis. Life Science Alliance 4, e202000764. * uses Xona’s Silicone Devices (RD900) with human iPSC-differentiated motor neurons
http://doi.org/10.26508/lsa.202000764
Tags: hiPSC-derived motor neurons, human, RD900
Zhang, Y., Li, C., Qin, Y., Cepparulo, P., Millman, M., Chopp, M., Kemper, A., Szalad, A., Lu, X., Wang, L., Zhang, Z.G., 2021. Small extracellular vesicles ameliorate peripheral neuropathy and enhance chemotherapy of oxaliplatin on ovarian cancer. Journal of Extracellular Vesicles 10, e12073. * uses Xona’s Silicone Devices (SND150) with mouse adult DRG neurons https://doi.org/10.1002/jev2.12073
Tags: adult, DRG, mouse, SND150
Katiyar, N., Raju, G., Madhusudanan, P., Gopalakrishnan-Prema, V., Shankarappa, S.A., 2021. Neuronal delivery of nanoparticles via nerve fibres in the skin. Sci Rep 11, 2566. * uses Xona’s Silicone Devices (SND150) with adult rat DRG neurons https://doi.org/10.1038/s41598-021-81995-x
Tags: adult, DRG, rat, SND150
Akin, E.J., Alsaloum, M., Higerd, G.P., Liu, S., Zhao, P., Dib-Hajj, F.B., Waxman, S.G., Dib-Hajj, S.D., 2021. Paclitaxel increases axonal localization and vesicular trafficking of Nav1.7. Brain. * uses Xona’s Silicone Devices (DOC450) with rat DRG neurons https://doi.org/10.1093/brain/awab113
Tags: DOC450, DRG, rat
Bhattacharyya, R., Black, S.E., Lotlikar, M.S., Fenn, R.H., Jorfi, M., Kovacs, D.M., Tanzi, R.E., 2021. Axonal generation of amyloid-β from palmitoylated APP in mitochondria-associated endoplasmic reticulum membranes. Cell Rep 35, 109134. * uses XonaChips® (XC150, XC450) with human NPCs cultured in 3D using Matrigel® https://doi.org/10.1016/j.celrep.2021.109134
Tags: 3D, human, Matrigel, NPC, XC150, XC450
Li, Yihang and Pazyra-Murphy, Maria F. and Avizonis, Daina and de Sa Tavares Russo, Mariana and Tang, Sophia and Bergholz, Johann S. and Jiang, Tao and Zhao, Jean J. and Zhu, Jian and Ko, Kwang Woo and Milbrandt, Jeffrey and DiAntonio, Aaron and Segal, Rosalind A., Activation of Sarm1 Produces cADPR to Increase Intra-Axonal Calcium and Promote Axon Degeneration in CIPN. Neuron * uses XonaChips® (XC900) http://dx.doi.org/10.2139/ssrn.3830010
Tags: XC900
Güner, F., Pozner, T., Krach, F., Prots, I., Loskarn, S., Schlötzer-Schrehardt, U., Winkler, J., Winner, B., Regensburger, M., 2021. Axon-Specific Mitochondrial Pathology in SPG11 Alpha Motor Neurons. Frontiers in Neuroscience 15. * uses Xona’s Silicone Devices (SND450) with human iPSC-differentiated motor neuron progenitors and human cerebellar astrocytes co-cultures. https://doi.org/10.3389/fnins.2021.680572
Tags: astrocytes, co-culture, hiPSC-derived, hiPSC-derived motor neurons, human, motor neurons, SND450
Fligor, C.M., Lavekar, S.S., Harkin, J., Shields, P.K., VanderWall, K.B., Huang, K.-C., Gomes, C., Meyer, J.S., 2021. Extension of retinofugal projections in an assembled model of human pluripotent stem cell-derived organoids. Stem Cell Reports. * uses XonaChips® (XC450) with hPSC-derived retinal ganglion neurons (RGCs) purified from retinal organoids https://doi.org/10.1016/j.stemcr.2021.05.009
Tags: hPSC-derived, retinal ganglion cells, retinal organoid, XC450
Lie, P.P.Y., Yang, D.-S., Stavrides, P., Goulbourne, C.N., Zheng, P., Mohan, P.S., Cataldo, A.M., Nixon, R.A., 2021. Post-Golgi carriers, not lysosomes, confer lysosomal properties to pre-degradative organelles in normal and dystrophic axons. Cell Rep 35, 109034. * uses Xona’s Silicone Devices (RD450) with embryonic mouse cortical neurons. https://doi.org/10.1016/j.celrep.2021.109034
Tags: cortical neurons, embryonic, mouse, RD450
van Erp, S., van Berkel, A.A., Feenstra, E.M., Sahoo, P.K., Wagstaff, L.J., Twiss, J.L., Fawcett, J.W., Eva, R., ffrench-Constant, C., 2021. Age-related loss of axonal regeneration is reflected by the level of local translation. Exp Neurol 339, 113594. * uses Xona’s Silicone Devices (RD450) with hESC-differentiated neurons. https://doi.org/10.1016/j.expneurol.2020.113594
Tags: hESC-derived, human, RD450
Stoklund Dittlau, K., Krasnow, E.N., Fumagalli, L., Vandoorne, T., Baatsen, P., Kerstens, A., Giacomazzi, G., Pavie, B., Rossaert, E., Beckers, J., Sampaolesi, M., Van Damme, P., Van Den Bosch, L., 2021. Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition. Stem Cell Reports 16, 2213-2227. * uses XonaChips® (XC150) and Xona’s Silicone Devices (SND75) with human iPSC-differentiated motor neurons and human mesoangioblasts (MAB)-derived myotubes to create in vitro NMJs.
https://doi.org/10.1016/j.stemcr.2021.03.029
Tags: hiPSC-derived motor neurons, human, neuromuscular junction (NMJ), SND75, XC150
Stoklund Dittlau, K., Krasnow, E.N., Fumagalli, L., Vandoorne, T., Baatsen, P., Kerstens, A., Giacomazzi, G., Pavie, B., Rossaert, E., Beckers, J., Sampaolesi, M., Van Damme, P., Van Den Bosch, L., 2021. Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices. JoVE, e62959. * uses XonaChips® (XC150) and Xona’s Silicone Devices (SND75) with human iPSC-differentiated motor neurons and human mesoangioblasts (MAB)-derived myotubes to create in vitro NMJs. http://doi.org/10.3791/62959
Tags: hiPSC-derived motor neurons, human, motor neurons, neuromuscular junction (NMJ), SND75, XC150