Dinamarca, M. C., L. Colombo, U. Brykczynska, A. Grimm, I. Fruh, I. Hossain, D. Gabriel, A. Eckert, M. Müller and E. Pecho-Vrieseling, 2023. Transmission-selective muscle pathology induced by the active propagation of mutant huntingtin across the human neuromuscular synapse. Front Mol Neurosci 16: 1287510. https://doi.org/10.3389%2Ffnmol.2023.1287510
Tags: iMD3, motor neurons, myotubes, XC450

Kropf, E., A. Shekari, S. Jaberi, A. Puri, C. Wu and M. Fahnestock, 2023. Age-induced nitrative stress decreases retrograde transport of proNGF via TrkA and increases proNGF retrograde transport and neurodegeneration via p75(NTR). Front Mol Neurosci 16: 1241420. https://doi.org/10.3389%2Ffnmol.2023.1241420
Tags: basal forebrain cholinergic neurons, primary, XC450

Smith, C. S., Z. Álvarez, R. Qiu, I. R. Sasselli, T. Clemons, J. A. Ortega, M. Vilela-Picos, H. Wellman, E. Kiskinis and S. I. Stupp, 2023. Enhanced Neuron Growth and Electrical Activity by a Supramolecular Netrin-1 Mimetic Nanofiber. ACS Nano 17(20): 19887-19902. https://doi.org/10.1021/acsnano.3c04572
Tags: XC450

Brummer, T., M. Schillner, F. Steffen, F. Kneilmann, B. Wasser, T. Uphaus, F. Zipp and S. Bittner, 2023. Spatial transcriptomics and neurofilament light chain reveal changes in lesion patterns in murine autoimmune neuroinflammation. Journal of Neuroinflammation 20(1): 262. * uses XC450 XonaChips with microglia-axon co-cultures.  https://doi.org/10.1186/s12974-023-02947-y
Tags: cortical neurons, microglia, primary, XC450

Boal, A. M., N. R. McGrady, X. Chamling, B. S. Kagitapalli, D. J. Zack, D. J. Calkins and M. L. Risner, 2023. Microfluidic Platforms Promote Polarization of Human-Derived Retinal Ganglion Cells That Model Axonopathy. Translational Vision Science & Technology 12(4): 1-1. * uses XC450 XonaChips with hESC-derived RGCs. https://doi.org/10.1167/tvst.12.4.1
Tags: hESC-derived, retinal ganglion cells, XC450

Aiken, J. and E. L. F. Holzbaur, 2023. Spastin locally amplifies microtubule dynamics to pattern the axon for presynaptic cargo delivery. bioRxiv. * uses XonaChip (XC450) with human iPSC-derived i3Neurons.  https://doi.org/10.1101%2F2023.08.08.552320
Tags: hiPSC-derived, human, i3Neurons, preprint, XC450

Salas-Lucia, F., C. Fekete, R. Sinkó, P. Egri, K. Rada, Y. Ruska, B. Gereben and A. C. Bianco, 2023. Axonal T3 uptake and transport can trigger thyroid hormone signaling in the brain. eLife 12: e82683. * uses XonaChips (XC450) with primary mouse cortical neurons. https://doi.org/10.7554/eLife.82683
Tags: cortical neurons, mouse, primary, XC450

Neel DV, Basu H, Gunner G, Bergstresser MD, Giadone RM, Chung H, Miao R, Chou V, Brody E, Jiang X, Lee E, Watts ME, Marques C, Held A, Wainger B, Lagier-Tourenne C, Zhang YJ, Petrucelli L, Young-Pearse TL, Chen-Plotkin AS, Rubin LL, Lieberman J, Chiu IM. Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration. Neuron. 2023 Apr 19;111(8):1222-1240.e9. * uses XonaChips® (XC450) and Xona’s Silicone Devices (RD450) using mouse cortical neurons. http://doi.org/10.1016/j.neuron.2023.02.019
Tags: cortical neurons, mouse, RD450, XC450

Limone, F., Guerra San Juan, I., Mitchell, J.M., Smith, J.L.M., Raghunathan, K., Meyer, D., Ghosh, S.D., Couto, A., Klim, J.R., Joseph, B.J., Gold, J., Mello, C.J., Nemesh, J., Smith, B.M., Verhage, M., McCarroll, S.A., Pietiläinen, O., Nehme, R., Eggan, K., 2023. Efficient generation of lower induced motor neurons by coupling Ngn2 expression with developmental cues. Cell Reports 42, 111896. * uses XonaChips® (XC450) with co-culture of human lower induced motor neurons (liMNs) and primary murine myoblasts. https://doi.org/10.1016/j.celrep.2022.111896
Tags: co-culture, hiPSC-derived motor neurons, myoblasts, XC450

Shekari, A., Fahnestock, M., 2022. Retrograde axonal transport of Neurotrophins in basal forebrain cholinergic neurons, Axonal Transport: Methods and Protocols: Springer, pp. 249-270.  * uses XonaChips® (XC450) and ChipTrays with rat or mouse basal forebrain cholinergic neurons. **PROTOCOL** https://doi.org/10.1007/978-1-0716-1990-2_13
Tags: basal forebrain cholinergic neurons, ChipTray, mouse, protocol, rat, XC450

Lotlikar, M.S., Tarantino, M.B., Jorfi, M., Kovacs, D.M., Tanzi, R.E., Bhattacharyya, R., 2022. Microfluidic separation of axonal and somal compartments of neural progenitor cells differentiated in a 3D matrix. STAR Protocols 3, 101028. * uses XonaChips® (XC150, XC450) with human NPCs cultured in 3D using Matrigel® **PROTOCOL** https://doi.org/10.1016/j.xpro.2021.101028
Tags: 3D, human, Matrigel, NPC, protocol, XC150, XC450

Huang, K.-C., Lou, S., Wang, C.-C., Thanawala, M.S., Turner, J., Fink, A., Ji, L., Sadaghiani, M., Huang, P., Dai, H., 2022. DeepNeurite™: Identification of neurites from non-specific binding of fluorescence probes through deep learning. FASEB BioAdvances 4, 170-179.  * uses XonaChips® (XC450) with adult mouse DRGs. https://doi.org/10.1096/fba.2021-00072
Tags: adult, DRG, mouse, XC450

Rodriguez, C.M., Bechek, S.C., Jones, G.L., Nakayama, L., Akiyama, T., Kim, G., Solow-Cordero, D.E., Strittmatter, S.M., Gitler, A.D., 2022. Targeting RTN4/NoGo-Receptor reduces levels of ALS protein ataxin-2. Cell Rep 41, 111505. * uses XonaChips® (XC450) with primary mouse cortical neurons https://doi.org/10.1016/j.celrep.2022.111505
Tags: cortical neurons, mouse, primary, XC450

Nella, K.T., Norton, B.M., Chang, H.-T., Heuer, R.A., Roque, C.B., Matsuoka, A.J., 2022. Bridging the electrode–neuron gap: finite element modeling of in vitro neurotrophin gradients to optimize neuroelectronic interfaces in the inner ear. Acta Biomaterialia 151, 360-378. https://doi.org/10.1016/j.actbio.2022.08.035
Tags: hiPSC-derived, human, spiral ganglion neurons, XC450

Woldegebriel, R., Kvist, J., White, M., Sinkko, M., Hänninen, S., Sainio, M.T., Torregrosa-Munumer, R., Harjuhaahto, S., Huber, N., Herukka, S.-K., Haapasalo, A., Carpen, O., Bassett, A., Ylikallio, E., Sreedharan, J., Tyynismaa, H., 2021. Peripheral neuropathy linked mRNA export factor GANP reshapes gene regulation in human motor neurons. bioRxiv,  * uses XonaChips® (XC450) https://doi.org/10.1101/2021.05.18.444636
Tags: hiPSC-derived motor neurons, human, preprint, XC450

Margarita, D.C., Laura, C., Urszula, B., Amandine, G., Natalia, T.E., Isabelle, F., Hossain, I., Daniela, G., Anne, E., Matthias, M., Eline, P.-V., 2021. Mutant huntingtin actively crosses neuromuscular synapses and causes transmission-selective pathology in human myotubes. bioRxiv, 2021.2007.2028.454044. https://doi.org/10.1101/2021.07.28.454044
Tags: co-culture, hiPSC-derived, human, neuromuscular junction (NMJ), preprint, XC450

Bhattacharyya, R., Black, S.E., Lotlikar, M.S., Fenn, R.H., Jorfi, M., Kovacs, D.M., Tanzi, R.E., 2021. Axonal generation of amyloid-β from palmitoylated APP in mitochondria-associated endoplasmic reticulum membranes. Cell Rep 35, 109134. * uses XonaChips® (XC150, XC450) with human NPCs cultured in 3D using Matrigel® https://doi.org/10.1016/j.celrep.2021.109134
Tags: 3D, human, Matrigel, NPC, XC150, XC450

Fligor, C.M., Lavekar, S.S., Harkin, J., Shields, P.K., VanderWall, K.B., Huang, K.-C., Gomes, C., Meyer, J.S., 2021. Extension of retinofugal projections in an assembled model of human pluripotent stem cell-derived organoids. Stem Cell Reports. * uses XonaChips® (XC450) with hPSC-derived retinal ganglion neurons (RGCs) purified from retinal organoids https://doi.org/10.1016/j.stemcr.2021.05.009
Tags: hPSC-derived, retinal ganglion cells, retinal organoid, XC450

Aravamudhan, P., Raghunathan, K., Konopka-Anstadt, J., Pathak, A., Sutherland, D.M., Carter, B.D., Dermody, T.S., 2020. Reovirus uses macropinocytosis-mediated entry and fast axonal transport to infect neurons. PLoS pathogens 16, e1008380-e1008380. PMID: 32109948 * uses XonaChips® (XC450) with rat DRG neurons  https://www.ncbi.nlm.nih.gov/pubmed/32109948
Tags: DRG, rat, XC450

Aravamudhan, P., Raghunathan, K., Dermody, T.S., 2020. Confocal Microscopy of Reovirus Transport in Living Dorsal Root Ganglion Neurons. Bio Protoc 10, e3825.  * uses XonaChips® (XC450) with rat DRG neurons http://doi.org/10.21769/BioProtoc.3825
Tags: DRG, rat, XC450

Paranjape, S. R., Nagendran, T., Poole, V., Harris, J., Taylor, A. M. (2019). Compartmentalization of Human Stem Cell-Derived Neurons within Pre-Assembled Plastic Microfluidic Chips J. Vis. Exp. (147), e59250, doi:10.3791/59250 (2019). * uses XonaChips® (XC150, XC450, XC900) with human stem cell derived glutamatergic neurons **authored by Xona scientists  https://www.jove.com/video/59250/compartmentalization-human-stem-cell-derived-neurons-within-pre?status=a61256k
Tags: glutamatergic, hiPSC-derived, human, protocol, XC150, XC450, XC900, Xona author

Shekari, A. & Fahnestock, M. (2019). Retrograde axonal transport of BDNF and proNGF diminishes with age in basal forebrain cholinergic neurons. Neurobiol. Aging, 84: 131-140, https://doi.org/10.1016/j.neurobiolaging.2019.07.018 * uses XonaChips® (XC450) with rat basal forebrain or cortical neurons  https://www.ncbi.nlm.nih.gov/pubmed/31574357
Tags: basal forebrain cholinergic neurons, cortical neurons, rat, XC450

Nagendran, T., V. Poole, J. Harris and A. M. Taylor, 2018. Use of Pre-Assembled Plastic Microfluidic Chips for Compartmentalizing Primary Murine Neurons. Journal of visualized experiments : JoVE(141). * uses XC150, XC450, XC900 XonaChips with rat hippocampal neurons.  https://dx.doi.org/10.3791/58421
Tags: hippocampal neurons, mouse, protocol, rat, XC150, XC450, XC900, Xona author

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