Pisciottani, A., L. Croci, F. Lauria, C. Marullo, E. Savino, A. Ambrosi, P. Podini, M. Marchioretto, F. Casoni, O. Cremona, S. Taverna, A. Quattrini, J.-M. Cioni, G. Viero, F. Codazzi and G. G. Consalez, 2023. Neuronal models of TDP-43 proteinopathy display reduced axonal translation, increased oxidative stress, and defective exocytosis. Frontiers in Cellular Neuroscience 17. https://doi.org/10.3389/fncel.2023.1253543
Tags: cortical neurons, mouse, primary, SND450

Moya-Alvarado, G., A. Aguirre-Soto and F. C. Bronfman, 2024. Multiple Labeling of Compartmentalized Cortical Neurons in Microfluidic Chambers. Bio Protoc 14(1): e4911. 10.21769/BioProtoc.4911
Tags: primary, RD450, SND450

Danastas, K., G. Guo, J. Merjane, N. Hong, A. Larsen, M. Miranda-Saksena and L. Cunningham Anthony, 2023. Interferon inhibits the release of herpes simplex virus-1 from the axons of sensory neurons. mBio 14(5): e01818-01823. https://doi.org/10.1128/mbio.01818-23
Tags: primary, rat, SND450, viral infection

Kakuda, K., K. Ikenaka, A. Kuma, J. Doi, C. Aguirre, N. Wang, T. Ajiki, C.-J. Choong, Y. Kimura, S. M. M. Badawy, T. Shima, S. Nakamura, K. Baba, S. Nagano, Y. Nagai, T. Yoshimori and H. Mochizuki, 2024. Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles. Proceedings of the National Academy of Sciences 121(1): e2312306120. https://doi.org/10.1073/pnas.2312306120
Tags: cortical neurons, mouse, SND450

Luczo, J. M., S. J. Edwards, K. Ardipradja, W. W. Suen, G. G. Au, G. A. Marsh, N. Godde, C. L. Rootes, J. Bingham and V. Sundaramoorthy, 2024. SARS-CoV and SARS-CoV-2 display limited neuronal infection and lack the ability to transmit within synaptically connected axons in stem cell–derived human neurons. Journal of NeuroVirology. * uses SND450s with human iPSC-derived NPCs. https://doi.org/10.1007/s13365-023-01187-3
Tags: hiPSC-derived, human, NPC, SND450

Wu, Z., R. Zhu, Y. Yu, J. Wang, X. Hu, W. Xu, Y. Ren, C. Li, Z. Zeng, B. Ma, N. Xie, G. Lin, B. Ma, R. Zhu, K. Ye and L. Cheng, 2023. Spinal cord injury-activated C/EBPβ-AEP axis mediates cognitive impairment through APP C586/Tau N368 fragments spreading. Progress in Neurobiology 227: 102467. https://doi.org/10.1016/j.pneurobio.2023.102467
Tags: hippocampal neurons, primary, SND450

Van Dyck, A., L. Masin, S. Bergmans, G. Schevenels, A. Beckers, B. Vanhollebeke and L. Moons, 2023. A new microfluidic model to study dendritic remodeling and mitochondrial dynamics during axonal regeneration of adult zebrafish retinal neurons. Frontiers in Molecular Neuroscience 16. https://doi.org/10.3389/fnmol.2023.1196504
Tags: adult, SND450, SOC450, XC pre-coat, zebrafish

Murata, H., Y. Yasui, K. Oiso, T. Ochi, N. Tomonobu, K.-i. Yamamoto, R. Kinoshita and M. Sakaguchi, 2023. STAT1/3 signaling suppresses axon degeneration and neuronal cell death through regulation of NAD+-biosynthetic and consuming enzymes. Cellular Signalling 108: 110717. * uses SND450 silicone devices with human iPSC-derived neurons  https://doi.org/10.1016/j.cellsig.2023.110717
Tags: hiPSC-derived, human, SND450

Subramani, M., M. J. Van Hook and I. Ahmad, 2023. Reproducible generation of human retinal ganglion cells from banked retinal progenitor cells: analysis of target recognition and IGF-1-mediated axon regeneration. Front Cell Dev Biol 11: 1214104. * uses SND450 silicone devices with human RGC  https://doi.org/10.3389%2Ffcell.2023.1214104
Tags: human, injury, retinal ganglion cells, SND450

Baker, C. A., S. Tyagi, G. P. Higerd-Rusli, S. Liu, P. Zhao, F. B. Dib-Hajj, S. G. Waxman and S. D. Dib-Hajj, 2023. Paclitaxel effects on axonal localization and vesicular trafficking of NaV1.8. Frontiers in Molecular Neuroscience 16. * Uses SND450 silicone devices with rat DRG neurons. https://doi.org/10.3389/fnmol.2023.1130123
Tags: DRG, rat, SND450

Siddiq, M. M., C. A. Toro, N. P. Johnson, J. Hansen, Y. Xiong, W. Mellado, R. E. Tolentino, K. Johnson, G. Jayaraman, Z. Suhail, L. Harlow, J. Dai, K. G. Beaumont, R. Sebra, D. E. Willis, C. P. Cardozo and R. Iyengar, 2023. Spinal cord injury regulates circular RNA expression in axons. Front Mol Neurosci 16: 1183315. * uses Xona's silicone devices (SND450) with primary cortical neurons https://doi.org/10.3389%2Ffnmol.2023.1183315
Tags: cortical neurons, injury, mouse, primary, rat, SND450

Alessandra, P., C. Laura, L. Fabio, M. Chiara, S. Elisa, A. Alessandro, P. Paola, M. Marta, C. Filippo, C. Ottavio, T. Stefano, Q. Angelo, C. Jean-Michel, V. Gabriella, C. Franca and G. G. Consalez, 2023. Two neuronal models of TDP-43 proteinopathy display reduced axonal translation, increased oxidative stress, and defective exocytosis. bioRxiv: 2023.2005.2017.540919. * uses Xona's silicone devices (SND450) with mouse cortical neurons.  https://doi.org/10.1101/2023.05.17.540919
Tags: cortical neurons, mouse, preprint, primary, SND450

Subramani, M., Hook, M.V., Rajamoorthy, M., Qiu, F., Ahmad, I., 2023. Human Retinal Ganglion Cells Respond to Evolutionarily Conserved Chemotropic Cues for Intra Retinal Guidance and Regeneration. bioRxiv, 2023.2002.2001.526677 * uses Xona’s Silicone Devices (SND450) with human retinal ganglion cells and rat retinal cells.  https://doi.org/10.1101/2023.02.01.526677
Tags: human, preprint, rat, retinal ganglion cells, SND450

Arsić, A., Nikić-Spiegel, I., 2022. The tail domain of neurofilament light chain accumulates in neuronal nuclei during oxidative injury. bioRxiv, 2022.2003.2003.481279. * uses Xona’s Silicone Devices (SND450) with primary mouse cortical neurons. https://doi.org/10.1101/2022.03.03.481279
Tags: cortical neurons, mouse, preprint, primary, SND450

Danastas, K., Larsen, A., Jobson, S., Guo, G., Cunningham, A.L., Miranda-Saksena, M., 2022. Herpes simplex virus-1 utilizes the host actin cytoskeleton for its release from axonal growth cones. PLOS Pathogens 18, e1010264. * uses Xona’s Silicone Devices (SND450) with rat DRG neurons https://doi.org/10.1371/journal.ppat.1010264
Tags: DRG, rat, SND450

Diaz-Amarilla, P., Arredondo, F., Dapueto, R., Boix, V., Carvalho, D., Santi, M.D., Vasilskis, E., Mesquita-Ribeiro, R., Dajas-Bailador, F., Abin-Carriquiry, J.A., Engler, H., Savio, E., 2022. Isolation and characterization of neurotoxic astrocytes derived from adult triple transgenic Alzheimer’s disease mice. Neurochemistry International 159, 105403. * uses Xona’s Silicone Devices (SND450). https://doi.org/10.1016/j.neuint.2022.105403
Tags: SND450

Lie Pearl, P.Y., Yoo, L., Goulbourne Chris, N., Berg Martin, J., Stavrides, P., Huo, C., Lee, J.-H., Nixon Ralph, A., Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca2+ efflux and disrupted by PSEN1 loss of function. Science Advances 8, eabj5716. * uses Xona’s Silicone Devices (SND450) with mouse cortical neurons. https://doi.org/10.1126/sciadv.abj5716
Tags: cortical neurons, mouse, SND450

Morikawa, M., Jerath, N.U., Ogawa, T., Morikawa, M., Tanaka, Y., Shy, M.E., Zuchner, S., Hirokawa, N., 2022. A neuropathy-associated kinesin KIF1A mutation hyper-stabilizes the motor-neck interaction during the ATPase cycle. The EMBO Journal 41, e108899. https://doi.org/10.15252/embj.2021108899
Tags: adult, DRG, mouse, SND450

Hofmann, M., Biller, L., Michel, U., Bähr, M., Koch, J.C., 2022. Cytoskeletal assembly in axonal outgrowth and regeneration analyzed on the nanoscale. Sci Rep 12, 14387. * uses Xona’s Silicone Devices (SND450) with primary rat cortical neurons. https://doi.org/10.1038/s41598-022-18562-5
Tags: cortical neurons, primary, rat, SND450

Siddiq, M.M., Hannila, S.S., Zorina, Y., Nikulina, E., Rabinovich, V., Hou, J., Huq, R., Richman, E.L., Tolentino, R.E., Hansen, J., Velenosi, A., Kwon, B.K., Tsirka, S.E., Maze, I., Sebra, R., Beaumont, K.G., Toro, C.A., Cardozo, C.P., Iyengar, R., Filbin, M.T., 2021. Extracellular histones, a new class of inhibitory molecules of CNS axonal regeneration. Brain Communications, fcab271.* uses Xona’s Silicone Devices (SND150, SND450) with rat DRG neurons http://doi.org/10.1093/braincomms/fcab271
Tags: DRG, rat, SND150, SND450

Güner, F., Pozner, T., Krach, F., Prots, I., Loskarn, S., Schlötzer-Schrehardt, U., Winkler, J., Winner, B., Regensburger, M., 2021. Axon-Specific Mitochondrial Pathology in SPG11 Alpha Motor Neurons. Frontiers in Neuroscience 15. * uses Xona’s Silicone Devices (SND450) with human iPSC-differentiated motor neuron progenitors and human cerebellar astrocytes co-cultures. https://doi.org/10.3389/fnins.2021.680572
Tags: astrocytes, co-culture, hiPSC-derived, hiPSC-derived motor neurons, human, motor neurons, SND450

Sundaramoorthy V, Green D, Locke K, O’Brien CM, Dearnley M, et al. (2020) Novel role of SARM1 mediated axonal degeneration in the pathogenesis of rabies. PLOS Pathogens 16(2): e1008343. * uses Xona’s Silicone Devices (SND450) with mouse cortical and DRG neurons https://doi.org/10.1371/journal.ppat.1008343
Tags: cortical neurons, DRG, mouse, SND450

Fukuda, Y., Pazyra-Murphy, M.F., Silagi, E.S., Tasdemir-Yilmaz, O.E., Li, Y., Rose, L., Yeoh, Z.C., Vangos, N.E., Geffken, E.A., Seo, H.-S., Adelmant, G., Bird, G.H., Walensky, L.D., Marto, J.A., Dhe-Paganon, S., Segal, R.A., 2020. Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival. Journal of Cell Biology 220. * uses XonaChips® (XC900), XonaPDL™, and Xona’s Silicone Devices (SND450) with rat DRG neurons https://doi.org/10.1083/jcb.202005051
Tags: DRG, rat, SND450, XC900, XonaPDL

Fujita, Y., Nakanishi, T., Ueno, M., Itohara, S., Yamashita, T., 2020. Netrin-G1 Regulates Microglial Accumulation along Axons and Supports the Survival of Layer V Neurons in the Postnatal Mouse Brain. Cell Rep 31, 107580. * uses Xona’s Silicone Devices (SND450) with mouse cortical neurons co-cultured with microglia  https://doi.org/10.1016/j.celrep.2020.107580
Tags: co-culture, cortical neurons, microglia, mouse, SND450

Leitão, L., Neto, E., Conceição, F., Monteiro, A., Couto, M., Alves, C.J., Sousa, D.M., Lamghari, M., 2020. Osteoblasts are inherently programmed to repel sensory innervation. Bone Research 8, 20. * uses Xona’s Silicone Devices (SND450) with mouse DRG neurons co-cultured with human mesenchymal stem cells (MSC)-differentiated osteoblasts  https://doi.org/10.1038/s41413-020-0096-1
Tags: co-culture, DRG, human, mouse, osteoblasts, SND450, stem cells

Cornejo, V.H., Gonzalez, C., Campos, M., Vargas-Saturno, L., Juricic, M.L.A., Miserey-Lenkei, S., Pertusa, M., Madrid, R., Couve, A., 2020. Non-conventional Axonal Organelles Control TRPM8 Ion Channel Trafficking and Peripheral Cold Sensing. Cell Rep 30, 4505-4517 e4505. * uses Xona’s Silicone Devices with mouse trigeminal and DRG neurons  https://doi.org/10.1016/j.celrep.2020.03.017
Tags: co-culture, DRG, mouse, SND450, trigeminal

Abo-Rady, M., Kalmbach, N., Pal, A., Schludi, C., Janosch, A., Richter, T., Freitag, P., Bickle, M., Kahlert, A.K., Petri, S., Stefanov, S., Glass, H., Staege, S., Just, W., Bhatnagar, R., Edbauer, D., Hermann, A., Wegner, F., Sterneckert, J.L., 2020. Knocking out C9ORF72 Exacerbates Axonal Trafficking Defects Associated with Hexanucleotide Repeat Expansion and Reduces Levels of Heat Shock Proteins. Stem Cell Reports 14, 390-405. * uses Xona’s Silicone Devices with human iPSC-differentiated motor neurons https://doi.org/10.1016%2Fj.stemcr.2020.01.010
Tags: hiPSC-derived motor neurons, SND450

Tian, N., Hanson, K.A., Canty, A.J., Vickers, J.C., King, A.E., 2020. Microtubule-dependent processes precede pathological calcium influx in excitotoxin-induced axon degeneration. J Neurochem 152, 542-555. * uses Xona’s Silicone Devices (SND450) with mouse cortical neurons https://doi.org/10.1111/jnc.14909
Tags: cortical neurons, mouse, SND450

Fujita, Y., Yamashita, T., 2020. Protocol for Co-culture of Microglia with Axons. STAR Protocols, 100111.  * uses Xona’s Silicone Devices (SND450) with mouse co-cultures with cortical neurons and microglia https://doi.org/10.1016/j.xpro.2020.100111
Tags: co-culture, cortical neurons, mouse, SND450

Zhang, Y., Qin, Y., Chopp, M., Li, C., Kemper, A., Liu, X., Wang, X., Zhang, L., Zhang Zheng, G., 2020. Ischemic Cerebral Endothelial Cell–Derived Exosomes Promote Axonal Growth. Stroke 51, 3701-3712. * uses Xona’s Silicone Devices (SND450, TCND500) with rat cortical neurons and exosomes isolated from cerebral endothelial cells (CECs) http://doi.org/10.1161/STROKEAHA.120.031728
Tags: cortical neurons, rat, SND450, TCND500

Lomoio S, Willen R, Kim W, Ho KZ, Robinson EK, Prokopenko D, Kennedy ME, Tanzi RE, Tesco G., 2020. Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer’s disease trigger BACE1 accumulation in axonal swellings. Sci Transl Med.  Nov 18;12(570):eaba1871. * uses Xona’s Silicone Devices (SND450) with mouse hippocampal neurons http://doi.org/10.1126/scitranslmed.aba1871
Tags: hippocampal neurons, mouse, SND450

Liu, M., Pi, H., Xi, Y., Wang, L., Tian, L., Chen, M., Xie, J., Deng, P., Zhang, T., Zhou, C., Liang, Y., Zhang, L., He, M., Lu, Y., Chen, C., Yu, Z., Zhou, Z., 2020. KIF5A-dependent axonal transport deficiency disrupts autophagic flux in trimethyltin chloride-induced neurotoxicity. Autophagy 17, 903-924.  * uses Xona’s Silicone Devices (SND450) https://doi.org/10.1080/15548627.2020.1739444
Tags: SND450

Li, C., Zhang, Y., Levin, A.M., Fan, B.Y., Teng, H., Ghannam, M.M., Chopp, M., Zhang, Z.G., 2019. Distal Axonal Proteins and Their Related MiRNAs in Cultured Cortical Neurons. Mol Neurobiol. Apr;56(4):2703-2713. doi: 10.1007/s12035-018-1266-7. * uses Xona’s Silicone Devices (SND450) with rat cortical neurons  https://www.ncbi.nlm.nih.gov/pubmed/30054858
Tags: cortical neurons, rat, SND450

Zhu, S., Zhu, J., Zhen, G., Hu, Y., An, S., Li, Y., Zheng, Q., Chen, Z., Yang, Y., Wan, M., Skolasky, R.L., Cao, Y., Wu, T., Gao, B., Yang, M., Gao, M., Kuliwaba, J., Ni, S., Wang, L., Wu, C., Findlay, D., Eltzschig, H.K., Ouyang, H.W., Crane, J., Zhou, F.-Q., Guan, Y., Dong, X., Cao, X., 2019. Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain. J Clin Invest. 2019 Mar 1;129(3):1076-1093. doi: 10.1172/JCI121561 * uses Xona’s Silicone Devices (SND450) with mouse DRG neurons https://www.ncbi.nlm.nih.gov/pubmed/30530994
Tags: DRG, mouse, SND450

Wang, L., Chopp, M., Lu, X., Szalad, A., Jia, L., Liu, X.S., Wu, K.-H., Lu, M., Zhang, Z.G., 2019. miR-146a mediates thymosin β4 induced neurovascular remodeling of diabetic peripheral neuropathy in type-II diabetic mice. Brain Res. Mar 15;1707:198-207. doi: 10.1016/j.brainres.2018.11.039 * uses Xona’s Silicone Devices (Cat. # not specified) with rat DRG neurons  https://www.ncbi.nlm.nih.gov/pubmed/30500399
Tags: DRG, rat, SND450

Bieri, G., Brahic, M., Bousset, L., Couthouis, J., Kramer, N.J., Ma, R., Nakayama, L., Monbureau, M., Defensor, E., Schüle, B., Shamloo, M., Melki, R., Gitler, A.D., 2019. LRRK2 modifies α-syn pathology and spread in mouse models and human neurons.  Acta Neuropathol. 2019 Mar 29. doi: 10.1007/s00401-019-01995-0. * uses Xona’s Silicone Devices (SND450) with human stem cell derived neurons  https://www.ncbi.nlm.nih.gov/pubmed/30927072
Tags: human, SND450, stem cells

Kamande, J.W., Nagendran, T., Harris, J., Taylor, A.M., 2019. Multi-compartment Microfluidic Device Geometry and Covalently Bound Poly-D-Lysine Influence Neuronal Maturation. Front. Bioeng. Biotechnol. | doi: 10.3389/fbioe.2019.00084. * uses Xona’s Silicone Devices (SND450, DOC450) with human stem cell derived glutamatergic neurons **Original research authored by Xona scientists**  https://www.frontiersin.org/articles/10.3389/fbioe.2019.00084/abstract
Tags: DOC450, glutamatergic, hiPSC-derived, human, SND450, Xona author

Pu, H., Shi, Y., Zhang, L., Lu, Z., Ye, Q., Leak, R.K., Xu, F., Ma, S., Mu, H., Wei, Z., Xu, N., Xia, Y., Hu, X., Hitchens, T.K., Bennett, M.V.L., Chen, J., 2019. Protease-independent action of tissue plasminogen activator in brain plasticity and neurological recovery after ischemic stroke. Proceedings of the National Academy of Sciences 116, 9115, doi: 10.1073/pnas.1821979116.* uses Xona’s Silicone Devices (SND450) with rat cortical neurons  https://www.ncbi.nlm.nih.gov/pubmed/30996120
Tags: cortical neurons, rat, SND450

Yan, K., Liu, J., Guan, X., Yin, Y. X., Peng, H., Chen, H. C., & Liu, Z. F. (2019). The Carboxyl Terminus of Tegument Protein pUL21 Contributes to Pseudorabies Virus Neuroinvasion. Journal of virology, 93(7), e02052-18. https://doi.org/10.1128/JVI.02052-18 * uses Xona’s Silicone Devices (SND450) with chicken DRG neurons  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430533/
Tags: chicken, DRG, SND450

Nijssen, J., Aguila, J. and Hedlund, E. (2019). Axon-seq for in Depth Analysis of the RNA Content of Neuronal Processes. Bio-protocol 9(14): e3312. DOI: 10.21769/BioProtoc.3312. * uses Xona’s Silicone Devices (SND150, SND450, SND900) with mouse and human stem cell derived motor neurons  https://bio-protocol.org/e3312
Tags: human, motor neurons, mouse, protocol, SND150, SND450, SND900, stem cells

Gruner, H.N., Bae, B., Lynch, M., Oliver, D., So, K., Mastick, G.S., Yan, W., Miura, P., 2019. Precise removal of Calm1 long 3′ UTR isoform by CRISPR-Cas9 genome editing impairs dorsal root ganglion development in mice. bioRxiv, 553990. * uses Xona’s Silicone Devices (SND450) with mouse DRG neurons  https://doi.org/10.1101/553990
Tags: DRG, mouse, SND450

Teotia, P., Van Hook, M.J., Fischer, D., Ahmad, I., 2019. Human retinal ganglion cell axon regeneration by recapitulating developmental mechanisms: effects of recruitment of the mTOR pathway. Development 146, dev178012. * uses Xona’s Silicone Devices (SND450) with human retinal ganglion cells   https://doi.org/10.1242/dev.178012
Tags: human, retinal ganglion cells, SND450

Van Laar, V. S., B. Arnold, E. H. Howlett, M. J. Calderon, C. M. St Croix, J. T. Greenamyre, L. H. Sanders and S. B. Berman, 2018. Evidence for Compartmentalized Axonal Mitochondrial Biogenesis: Mitochondrial DNA Replication Increases in Distal Axons As an Early Response to Parkinson's Disease-Relevant Stress. J Neurosci 38(34): 7505-7515. https://doi.org/10.1523/jneurosci.0541-18.2018
Tags: cortical neurons, rat, SND450, SND900

Nagendran, T., R. S. Larsen, R. L. Bigler, S. B. Frost, B. D. Philpot, R. J. Nudo and A. M. Taylor, 2017. Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling. Nature Communications 8(1): 625. https://doi.org/10.1038/s41467-017-00652-y
Tags: hippocampal neurons, rat, SND450, SND900, Xona author

Taylor, A. M., D. C. Dieterich, H. T. Ito, S. A. Kim and E. M. Schuman, 2010. Microfluidic local perfusion chambers for the visualization and manipulation of synapses. Neuron 66(1): 57-68. https://doi.org/10.1016/j.neuron.2010.03.022
Tags: hippocampal neurons, microfluidic local perfusion device, primary, rat, SND150, SND450, SND900, uLP, Xona author

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