Murata, H., Y. Yasui, K. Oiso, T. Ochi, N. Tomonobu, K.-i. Yamamoto, R. Kinoshita and M. Sakaguchi, 2023. STAT1/3 signaling suppresses axon degeneration and neuronal cell death through regulation of NAD+-biosynthetic and consuming enzymes. Cellular Signalling 108: 110717. * uses SND450 silicone devices with human iPSC-derived neurons https://doi.org/10.1016/j.cellsig.2023.110717
Tags: hiPSC-derived, human, SND450
Subramani, M., M. J. Van Hook and I. Ahmad, 2023. Reproducible generation of human retinal ganglion cells from banked retinal progenitor cells: analysis of target recognition and IGF-1-mediated axon regeneration. Front Cell Dev Biol 11: 1214104. * uses SND450 silicone devices with human RGC https://doi.org/10.3389%2Ffcell.2023.1214104
Tags: human, injury, retinal ganglion cells, SND450
Baker, C. A., S. Tyagi, G. P. Higerd-Rusli, S. Liu, P. Zhao, F. B. Dib-Hajj, S. G. Waxman and S. D. Dib-Hajj, 2023. Paclitaxel effects on axonal localization and vesicular trafficking of NaV1.8. Frontiers in Molecular Neuroscience 16. * Uses SND450 silicone devices with rat DRG neurons. https://doi.org/10.3389/fnmol.2023.1130123
Tags: DRG, rat, SND450
Siddiq, M. M., C. A. Toro, N. P. Johnson, J. Hansen, Y. Xiong, W. Mellado, R. E. Tolentino, K. Johnson, G. Jayaraman, Z. Suhail, L. Harlow, J. Dai, K. G. Beaumont, R. Sebra, D. E. Willis, C. P. Cardozo and R. Iyengar, 2023. Spinal cord injury regulates circular RNA expression in axons. Front Mol Neurosci 16: 1183315. * uses Xona's silicone devices (SND450) with primary cortical neurons https://doi.org/10.3389%2Ffnmol.2023.1183315
Tags: cortical neurons, injury, mouse, primary, rat, SND450
Alessandra, P., C. Laura, L. Fabio, M. Chiara, S. Elisa, A. Alessandro, P. Paola, M. Marta, C. Filippo, C. Ottavio, T. Stefano, Q. Angelo, C. Jean-Michel, V. Gabriella, C. Franca and G. G. Consalez, 2023. Two neuronal models of TDP-43 proteinopathy display reduced axonal translation, increased oxidative stress, and defective exocytosis. bioRxiv: 2023.2005.2017.540919. * uses Xona's silicone devices (SND450) with mouse cortical neurons. https://doi.org/10.1101/2023.05.17.540919
Tags: cortical neurons, mouse, preprint, primary, SND450
Subramani, M., Hook, M.V., Rajamoorthy, M., Qiu, F., Ahmad, I., 2023. Human Retinal Ganglion Cells Respond to Evolutionarily Conserved Chemotropic Cues for Intra Retinal Guidance and Regeneration. bioRxiv, 2023.2002.2001.526677 * uses Xona’s Silicone Devices (SND450) with human retinal ganglion cells and rat retinal cells. https://doi.org/10.1101/2023.02.01.526677
Tags: human, preprint, rat, retinal ganglion cells, SND450
Arsić, A., Nikić-Spiegel, I., 2022. The tail domain of neurofilament light chain accumulates in neuronal nuclei during oxidative injury. bioRxiv, 2022.2003.2003.481279. * uses Xona’s Silicone Devices (SND450) with primary mouse cortical neurons. https://doi.org/10.1101/2022.03.03.481279
Tags: cortical neurons, mouse, preprint, primary, SND450
Danastas, K., Larsen, A., Jobson, S., Guo, G., Cunningham, A.L., Miranda-Saksena, M., 2022. Herpes simplex virus-1 utilizes the host actin cytoskeleton for its release from axonal growth cones. PLOS Pathogens 18, e1010264. * uses Xona’s Silicone Devices (SND450) with rat DRG neurons
https://doi.org/10.1371/journal.ppat.1010264
Tags: DRG, rat, SND450
Diaz-Amarilla, P., Arredondo, F., Dapueto, R., Boix, V., Carvalho, D., Santi, M.D., Vasilskis, E., Mesquita-Ribeiro, R., Dajas-Bailador, F., Abin-Carriquiry, J.A., Engler, H., Savio, E., 2022. Isolation and characterization of neurotoxic astrocytes derived from adult triple transgenic Alzheimer’s disease mice. Neurochemistry International 159, 105403. * uses Xona’s Silicone Devices (SND450). https://doi.org/10.1016/j.neuint.2022.105403
Tags: SND450
Lie Pearl, P.Y., Yoo, L., Goulbourne Chris, N., Berg Martin, J., Stavrides, P., Huo, C., Lee, J.-H., Nixon Ralph, A., Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca2+ efflux and disrupted by PSEN1 loss of function. Science Advances 8, eabj5716. * uses Xona’s Silicone Devices (SND450) with mouse cortical neurons. https://doi.org/10.1126/sciadv.abj5716
Tags: cortical neurons, mouse, SND450
Morikawa, M., Jerath, N.U., Ogawa, T., Morikawa, M., Tanaka, Y., Shy, M.E., Zuchner, S., Hirokawa, N., 2022. A neuropathy-associated kinesin KIF1A mutation hyper-stabilizes the motor-neck interaction during the ATPase cycle. The EMBO Journal 41, e108899. https://doi.org/10.15252/embj.2021108899
Tags: adult, DRG, mouse, SND450
Hofmann, M., Biller, L., Michel, U., Bähr, M., Koch, J.C., 2022. Cytoskeletal assembly in axonal outgrowth and regeneration analyzed on the nanoscale. Sci Rep 12, 14387. * uses Xona’s Silicone Devices (SND450) with primary rat cortical neurons. https://doi.org/10.1038/s41598-022-18562-5
Tags: cortical neurons, primary, rat, SND450
Siddiq, M.M., Hannila, S.S., Zorina, Y., Nikulina, E., Rabinovich, V., Hou, J., Huq, R., Richman, E.L., Tolentino, R.E., Hansen, J., Velenosi, A., Kwon, B.K., Tsirka, S.E., Maze, I., Sebra, R., Beaumont, K.G., Toro, C.A., Cardozo, C.P., Iyengar, R., Filbin, M.T., 2021. Extracellular histones, a new class of inhibitory molecules of CNS axonal regeneration. Brain Communications, fcab271.* uses Xona’s Silicone Devices (SND150, SND450) with rat DRG neurons http://doi.org/10.1093/braincomms/fcab271
Tags: DRG, rat, SND150, SND450
Güner, F., Pozner, T., Krach, F., Prots, I., Loskarn, S., Schlötzer-Schrehardt, U., Winkler, J., Winner, B., Regensburger, M., 2021. Axon-Specific Mitochondrial Pathology in SPG11 Alpha Motor Neurons. Frontiers in Neuroscience 15. * uses Xona’s Silicone Devices (SND450) with human iPSC-differentiated motor neuron progenitors and human cerebellar astrocytes co-cultures. https://doi.org/10.3389/fnins.2021.680572
Tags: astrocytes, co-culture, hiPSC-derived, hiPSC-derived motor neurons, human, motor neurons, SND450
Sundaramoorthy V, Green D, Locke K, O’Brien CM, Dearnley M, et al. (2020) Novel role of SARM1 mediated axonal degeneration in the pathogenesis of rabies. PLOS Pathogens 16(2): e1008343. * uses Xona’s Silicone Devices (SND450) with mouse cortical and DRG neurons https://doi.org/10.1371/journal.ppat.1008343
Tags: cortical neurons, DRG, mouse, SND450
Fukuda, Y., Pazyra-Murphy, M.F., Silagi, E.S., Tasdemir-Yilmaz, O.E., Li, Y., Rose, L., Yeoh, Z.C., Vangos, N.E., Geffken, E.A., Seo, H.-S., Adelmant, G., Bird, G.H., Walensky, L.D., Marto, J.A., Dhe-Paganon, S., Segal, R.A., 2020. Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival. Journal of Cell Biology 220. * uses XonaChips® (XC900), XonaPDL™, and Xona’s Silicone Devices (SND450) with rat DRG neurons https://doi.org/10.1083/jcb.202005051
Tags: DRG, rat, SND450, XC900, XonaPDL
Fujita, Y., Nakanishi, T., Ueno, M., Itohara, S., Yamashita, T., 2020. Netrin-G1 Regulates Microglial Accumulation along Axons and Supports the Survival of Layer V Neurons in the Postnatal Mouse Brain. Cell Rep 31, 107580. * uses Xona’s Silicone Devices (SND450) with mouse cortical neurons co-cultured with microglia https://doi.org/10.1016/j.celrep.2020.107580
Tags: co-culture, cortical neurons, microglia, mouse, SND450
Leitão, L., Neto, E., Conceição, F., Monteiro, A., Couto, M., Alves, C.J., Sousa, D.M., Lamghari, M., 2020. Osteoblasts are inherently programmed to repel sensory innervation. Bone Research 8, 20. * uses Xona’s Silicone Devices (SND450) with mouse DRG neurons co-cultured with human mesenchymal stem cells (MSC)-differentiated osteoblasts https://doi.org/10.1038/s41413-020-0096-1
Tags: co-culture, DRG, human, mouse, osteoblasts, SND450, stem cells
Cornejo, V.H., Gonzalez, C., Campos, M., Vargas-Saturno, L., Juricic, M.L.A., Miserey-Lenkei, S., Pertusa, M., Madrid, R., Couve, A., 2020. Non-conventional Axonal Organelles Control TRPM8 Ion Channel Trafficking and Peripheral Cold Sensing. Cell Rep 30, 4505-4517 e4505. * uses Xona’s Silicone Devices with mouse trigeminal and DRG neurons https://doi.org/10.1016/j.celrep.2020.03.017
Tags: co-culture, DRG, mouse, SND450, trigeminal
Abo-Rady, M., Kalmbach, N., Pal, A., Schludi, C., Janosch, A., Richter, T., Freitag, P., Bickle, M., Kahlert, A.K., Petri, S., Stefanov, S., Glass, H., Staege, S., Just, W., Bhatnagar, R., Edbauer, D., Hermann, A., Wegner, F., Sterneckert, J.L., 2020. Knocking out C9ORF72 Exacerbates Axonal Trafficking Defects Associated with Hexanucleotide Repeat Expansion and Reduces Levels of Heat Shock Proteins. Stem Cell Reports 14, 390-405. * uses Xona’s Silicone Devices with human iPSC-differentiated motor neurons https://doi.org/10.1016%2Fj.stemcr.2020.01.010
Tags: hiPSC-derived motor neurons, SND450
Tian, N., Hanson, K.A., Canty, A.J., Vickers, J.C., King, A.E., 2020. Microtubule-dependent processes precede pathological calcium influx in excitotoxin-induced axon degeneration. J Neurochem 152, 542-555. * uses Xona’s Silicone Devices (SND450) with mouse cortical neurons https://doi.org/10.1111/jnc.14909
Tags: cortical neurons, mouse, SND450
Fujita, Y., Yamashita, T., 2020. Protocol for Co-culture of Microglia with Axons. STAR Protocols, 100111. * uses Xona’s Silicone Devices (SND450) with mouse co-cultures with cortical neurons and microglia https://doi.org/10.1016/j.xpro.2020.100111
Tags: co-culture, cortical neurons, mouse, SND450
Zhang, Y., Qin, Y., Chopp, M., Li, C., Kemper, A., Liu, X., Wang, X., Zhang, L., Zhang Zheng, G., 2020. Ischemic Cerebral Endothelial Cell–Derived Exosomes Promote Axonal Growth. Stroke 51, 3701-3712. * uses Xona’s Silicone Devices (SND450, TCND500) with rat cortical neurons and exosomes isolated from cerebral endothelial cells (CECs) http://doi.org/10.1161/STROKEAHA.120.031728
Tags: cortical neurons, rat, SND450, TCND500
Lomoio S, Willen R, Kim W, Ho KZ, Robinson EK, Prokopenko D, Kennedy ME, Tanzi RE, Tesco G., 2020. Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer’s disease trigger BACE1 accumulation in axonal swellings. Sci Transl Med. Nov 18;12(570):eaba1871. * uses Xona’s Silicone Devices (SND450) with mouse hippocampal neurons http://doi.org/10.1126/scitranslmed.aba1871
Tags: hippocampal neurons, mouse, SND450
Liu, M., Pi, H., Xi, Y., Wang, L., Tian, L., Chen, M., Xie, J., Deng, P., Zhang, T., Zhou, C., Liang, Y., Zhang, L., He, M., Lu, Y., Chen, C., Yu, Z., Zhou, Z., 2020. KIF5A-dependent axonal transport deficiency disrupts autophagic flux in trimethyltin chloride-induced neurotoxicity. Autophagy 17, 903-924. * uses Xona’s Silicone Devices (SND450) https://doi.org/10.1080/15548627.2020.1739444
Tags: SND450
Li, C., Zhang, Y., Levin, A.M., Fan, B.Y., Teng, H., Ghannam, M.M., Chopp, M., Zhang, Z.G., 2019. Distal Axonal Proteins and Their Related MiRNAs in Cultured Cortical Neurons. Mol Neurobiol. Apr;56(4):2703-2713. doi: 10.1007/s12035-018-1266-7. * uses Xona’s Silicone Devices (SND450) with rat cortical neurons https://www.ncbi.nlm.nih.gov/pubmed/30054858
Tags: cortical neurons, rat, SND450
Zhu, S., Zhu, J., Zhen, G., Hu, Y., An, S., Li, Y., Zheng, Q., Chen, Z., Yang, Y., Wan, M., Skolasky, R.L., Cao, Y., Wu, T., Gao, B., Yang, M., Gao, M., Kuliwaba, J., Ni, S., Wang, L., Wu, C., Findlay, D., Eltzschig, H.K., Ouyang, H.W., Crane, J., Zhou, F.-Q., Guan, Y., Dong, X., Cao, X., 2019. Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain. J Clin Invest. 2019 Mar 1;129(3):1076-1093. doi: 10.1172/JCI121561 * uses Xona’s Silicone Devices (SND450) with mouse DRG neurons https://www.ncbi.nlm.nih.gov/pubmed/30530994
Tags: DRG, mouse, SND450
Wang, L., Chopp, M., Lu, X., Szalad, A., Jia, L., Liu, X.S., Wu, K.-H., Lu, M., Zhang, Z.G., 2019. miR-146a mediates thymosin β4 induced neurovascular remodeling of diabetic peripheral neuropathy in type-II diabetic mice.
Brain Res. Mar 15;1707:198-207. doi: 10.1016/j.brainres.2018.11.039 * uses Xona’s Silicone Devices (Cat. # not specified) with rat DRG neurons https://www.ncbi.nlm.nih.gov/pubmed/30500399
Tags: DRG, rat, SND450
Bieri, G., Brahic, M., Bousset, L., Couthouis, J., Kramer, N.J., Ma, R., Nakayama, L., Monbureau, M., Defensor, E., Schüle, B., Shamloo, M., Melki, R., Gitler, A.D., 2019. LRRK2 modifies α-syn pathology and spread in mouse models and human neurons. Acta Neuropathol. 2019 Mar 29. doi: 10.1007/s00401-019-01995-0. * uses Xona’s Silicone Devices (SND450) with human stem cell derived neurons https://www.ncbi.nlm.nih.gov/pubmed/30927072
Tags: human, SND450, stem cells
Kamande, J.W., Nagendran, T., Harris, J., Taylor, A.M., 2019. Multi-compartment Microfluidic Device Geometry and Covalently Bound Poly-D-Lysine Influence Neuronal Maturation. Front. Bioeng. Biotechnol. | doi: 10.3389/fbioe.2019.00084. * uses Xona’s Silicone Devices (SND450, DOC450) with human stem cell derived glutamatergic neurons **Original research authored by Xona scientists** https://www.frontiersin.org/articles/10.3389/fbioe.2019.00084/abstract
Tags: DOC450, glutamatergic, hiPSC-derived, human, SND450, Xona author
Pu, H., Shi, Y., Zhang, L., Lu, Z., Ye, Q., Leak, R.K., Xu, F., Ma, S., Mu, H., Wei, Z., Xu, N., Xia, Y., Hu, X., Hitchens, T.K., Bennett, M.V.L., Chen, J., 2019. Protease-independent action of tissue plasminogen activator in brain plasticity and neurological recovery after ischemic stroke. Proceedings of the National Academy of Sciences 116, 9115, doi: 10.1073/pnas.1821979116.* uses Xona’s Silicone Devices (SND450) with rat cortical neurons https://www.ncbi.nlm.nih.gov/pubmed/30996120
Tags: cortical neurons, rat, SND450
Yan, K., Liu, J., Guan, X., Yin, Y. X., Peng, H., Chen, H. C., & Liu, Z. F. (2019). The Carboxyl Terminus of Tegument Protein pUL21 Contributes to Pseudorabies Virus Neuroinvasion. Journal of virology, 93(7), e02052-18. https://doi.org/10.1128/JVI.02052-18 * uses Xona’s Silicone Devices (SND450) with chicken DRG neurons https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430533/
Tags: chicken, DRG, SND450
Nijssen, J., Aguila, J. and Hedlund, E. (2019). Axon-seq for in Depth Analysis of the RNA Content of Neuronal Processes. Bio-protocol 9(14): e3312. DOI: 10.21769/BioProtoc.3312. * uses Xona’s Silicone Devices (SND150, SND450, SND900) with mouse and human stem cell derived motor neurons https://bio-protocol.org/e3312
Tags: human, motor neurons, mouse, protocol, SND150, SND450, SND900, stem cells
Goto-Silva, L., McShane, M.P., Salinas, S., Kalaidzidis, Y., Schiavo, G., Zerial, M., 2019. Retrograde transport of Akt by a neuronal Rab5-APPL1 endosome. Sci Rep 9, 2433. * uses Xona’s Silicone Devices (cat # not specified) with rat DRG neurons https://doi.org/10.1038/s41598-019-38637-0
Tags: DRG, rat, SND450
Gruner, H.N., Bae, B., Lynch, M., Oliver, D., So, K., Mastick, G.S., Yan, W., Miura, P., 2019. Precise removal of Calm1 long 3′ UTR isoform by CRISPR-Cas9 genome editing impairs dorsal root ganglion development in mice. bioRxiv, 553990. * uses Xona’s Silicone Devices (SND450) with mouse DRG neurons https://doi.org/10.1101/553990
Tags: DRG, mouse, SND450
Teotia, P., Van Hook, M.J., Fischer, D., Ahmad, I., 2019. Human retinal ganglion cell axon regeneration by recapitulating developmental mechanisms: effects of recruitment of the mTOR pathway. Development 146, dev178012. * uses Xona’s Silicone Devices (SND450) with human retinal ganglion cells
https://doi.org/10.1242/dev.178012
Tags: human, retinal ganglion cells, SND450
Van Laar, V. S., B. Arnold, E. H. Howlett, M. J. Calderon, C. M. St Croix, J. T. Greenamyre, L. H. Sanders and S. B. Berman, 2018. Evidence for Compartmentalized Axonal Mitochondrial Biogenesis: Mitochondrial DNA Replication Increases in Distal Axons As an Early Response to Parkinson's Disease-Relevant Stress. J Neurosci 38(34): 7505-7515. https://doi.org/10.1523/jneurosci.0541-18.2018
Tags: cortical neurons, rat, SND450, SND900
Nagendran, T., R. S. Larsen, R. L. Bigler, S. B. Frost, B. D. Philpot, R. J. Nudo and A. M. Taylor, 2017. Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling. Nature Communications 8(1): 625. https://doi.org/10.1038/s41467-017-00652-y
Tags: hippocampal neurons, rat, SND450, SND900, Xona author
Taylor, A. M., D. C. Dieterich, H. T. Ito, S. A. Kim and E. M. Schuman, 2010. Microfluidic local perfusion chambers for the visualization and manipulation of synapses. Neuron 66(1): 57-68. https://doi.org/10.1016/j.neuron.2010.03.022
Tags: hippocampal neurons, microfluidic local perfusion device, primary, rat, SND150, SND450, SND900, uLP, Xona author