Uechi, H., S. Sridharan, J. Nijssen, J. Bilstein, J. M. Iglesias-Artola, S. Kishigami, V. Casablancas-Antras, I. Poser, E. J. Martinez, E. Boczek, M. Wagner, N. Tomschke, A. M. de Jesus Domingues, A. Pal, T. Doeleman, S. Kour, E. N. Anderson, F. Stein, H. O. Lee, X. Zhang, A. W. Fritsch, M. Jahnel, J. Fürsch, A. C. Murthy, S. Alberti, M. Bickle, N. L. Fawzi, A. Nadler, D. C. David, U. B. Pandey, A. Hermann, F. Stengel, B. G. Davis, A. J. Baldwin, M. M. Savitski, A. A. Hyman and R. J. Wheeler (2025). "Small-molecule dissolution of stress granules by redox modulation benefits ALS models." Nature Chemical Biology. https://doi.org/10.1038/s41589-025-01893-5
Tags: RD900
Pal, A., D. Grossmann, H. Glaß, V. Zimyanin, R. Günther, M. Catinozzi, T. M. Boeckers, J. Sterneckert, E. Storkebaum, S. Petri, F. Wegner, S. W. Grill, F. Pan-Montojo and A. Hermann (2024). "Glycolic acid and D-lactate—putative products of DJ-1—restore neurodegeneration in FUS - and SOD1-ALS." Life Science Alliance 7(8): e202302535. 10.26508/lsa.202302535
Tags: mitochondria tracking, RD900
Hartmann, C., M. Anskat, M. Ehrlich, J. Sterneckert, A. Pal and A. Hermann (2024) "MAPT Mutations V337M and N297K Alter Organelle Trafficking in Frontotemporal Dementia Patient-Specific Motor Neurons." Biomedicines 12 https://doi.org/10.3390/biomedicines12030641
Tags: human, NPC, RD900, spinal motor neurons
Arun, P., G. Dajana, G. Hannes, Z. Vitaly, G. René, C. Marica, M. B. Tobias, S. Jared, S. Erik, P. Susanne, W. Florian, G. Stefan, P.-M. Francisco and H. Andreas, 2023. DJ-1 products glycolic acid and D-lactate restore deficient axonal trafficking and DNA damage response in FUS and SOD1-associated amyotrophic lateral sclerosis. bioRxiv: 2023.2009.2020.558653. 10.1101/2023.09.20.558653
Tags: hiPSC-derived, hiPSC-derived motor neurons, motor neurons, preprint, RD900
Kandhavivorn, W., H. Glaß, T. Herrmannsdörfer, T. M. Böckers, M. Uhlarz, J. Gronemann, R. H. W. Funk, J. Pietzsch, A. Pal and A. Hermann, 2023. Restoring Axonal Organelle Motility and Regeneration in Cultured FUS-ALS Motoneurons through Magnetic Field Stimulation Suggests an Alternative Therapeutic Approach. Cells 12 DOI: 10.3390/cells12111502. * uses Xona's silicone devices (RD900) with hiPSC-derived motor neurons. https://doi.org/10.3390/cells12111502
Tags: hiPSC-derived motor neurons, RD900
Zimyanin, V. L., A.-M. Pielka, H. Glaß, J. Japtok, D. Großmann, M. Martin, A. Deussen, B. Szewczyk, C. Deppmann, E. Zunder, P. M. Andersen, T. M. Boeckers, J. Sterneckert, S. Redemann, A. Storch and A. Hermann, 2023. Live Cell Imaging of ATP Levels Reveals Metabolic Compartmentalization within Motoneurons and Early Metabolic Changes in FUS ALS Motoneurons. Cells 12 DOI: 10.3390/cells12101352. * uses Xona's silicone devices (RD900) with human iPSC-derived motoneurons. https://doi.org/10.3390/cells12101352
Tags: hiPSC-derived motor neurons, human, RD900
Marrone, L., Marchi, P.M., Webster, C.P., Marroccella, R., Coldicott, I., Reynolds, S., Alves-Cruzeiro, J., Yang, Z.-L., Higginbottom, A., Khundadze, M., Shaw, P.J., Hübner, C.A., Livesey, M.R., Azzouz, M., 2022. SPG15 protein deficits are at the crossroads between lysosomal abnormalities, altered lipid metabolism and synaptic dysfunction. Human Molecular Genetics 31, 2693-2710. * uses Xona’s Silicone Devices (RD900) with mouse cortical neurons. https://doi.org/10.1093/hmg/ddac063
Tags: cortical neurons, mouse, RD900
Günther, R., Pal, A., Williams, C., Zimyanin, V.L., Liehr, M., von Neubeck, C., Krause, M., Parab, M.G., Petri, S., Kalmbach, N., Marklund, S.L., Sterneckert, J., Munch Andersen, P., Wegner, F., Gilthorpe, J.D., Hermann, A., 2022. Alteration of Mitochondrial Integrity as Upstream Event in the Pathophysiology of SOD1-ALS, Cells. * uses Xona’s Silicone Devices (RD900) with hiPSC-derived motor neurons. https://doi.org/10.3390/cells11071246
Tags: ALS, hiPSC-derived motor neurons, RD900
Kulkarni, V.V., Stempel, M.H., Anand, A., Sidibe, D.K., Maday, S., 2022. Retrograde Axonal Autophagy and Endocytic Pathways Are Parallel and Separate in Neurons. The Journal of Neuroscience 42, 8524. https://doi.org/10.1523/JNEUROSCI.1292-22.2022
Tags: astrocytes, co-culture, cortical neurons, mouse, RD900
Pal, A., Kretner, B., Abo-Rady, M., Glaβ, H., Dash, B.P., Naumann, M., Japtok, J., Kreiter, N., Dhingra, A., Heutink, P., Böckers, T.M., Günther, R., Sterneckert, J., Hermann, A., 2021. Concomitant gain and loss of function pathomechanisms in C9ORF72 amyotrophic lateral sclerosis. Life Science Alliance 4, e202000764. * uses Xona’s Silicone Devices (RD900) with human iPSC-differentiated motor neurons
http://doi.org/10.26508/lsa.202000764
Tags: hiPSC-derived motor neurons, human, RD900
Naumann, M., Pal, A., Goswami, A., Lojewski, X., Japtok, J., Vehlow, A., Naujock, M., Günther, R., Jin, M., Stanslowsky, N., Reinhardt, P., Sterneckert, J., Frickenhaus, M., Pan-Montojo, F., Storkebaum, E., Poser, I., Freischmidt, A., Weishaupt, J.H., Holzmann, K., Troost, D., Ludolph, A.C., Boeckers, T.M., Liebau, S., Petri, S., Cordes, N., Hyman, A.A., Wegner, F., Grill, S.W., Weis, J., Storch, A., Hermann, A., 2018. Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation. Nature Communications 9, 335. * uses Xona’s Silicone Devices (RD900) with human iPSC-differentiated motor neurons https://doi.org/10.1038/s41467-017-02299-1
Tags: hiPSC-derived motor neurons, human, RD900