Danastas, K., G. Guo, J. Merjane, N. Hong, A. Larsen, M. Miranda-Saksena and L. Cunningham Anthony, 2023. Interferon inhibits the release of herpes simplex virus-1 from the axons of sensory neurons. mBio 14(5): e01818-01823. https://doi.org/10.1128/mbio.01818-23
Tags: primary, rat, SND450, viral infection

Gu, M., X. Cheng, D. Zhang, W. Wu, Y. Cao and J. He, 2024. Chemokine platelet factor 4 accelerates peripheral nerve regeneration by regulating Schwann cell activation and axon elongation. Neural Regeneration Research 19(1). * uses SND150 with rat DRG neurons. http://10.4103/1673-5374.375346
Tags: DRG, injury, rat, SND150

Gu, M., X. Li, R. Wu, X. Cheng, S. Zhou and X. Gu, 2023. The Transcription Factor Ets1 Influences Axonal Growth via Regulation of Lcn2. Molecular Neurobiology. https://doi.org/10.1007/s12035-023-03616-0
Tags: embryonic, injury, rat, SND150, spinal cord neurons

Baker, C. A., S. Tyagi, G. P. Higerd-Rusli, S. Liu, P. Zhao, F. B. Dib-Hajj, S. G. Waxman and S. D. Dib-Hajj, 2023. Paclitaxel effects on axonal localization and vesicular trafficking of NaV1.8. Frontiers in Molecular Neuroscience 16. * Uses SND450 silicone devices with rat DRG neurons. https://doi.org/10.3389/fnmol.2023.1130123
Tags: DRG, rat, SND450

Siddiq, M. M., C. A. Toro, N. P. Johnson, J. Hansen, Y. Xiong, W. Mellado, R. E. Tolentino, K. Johnson, G. Jayaraman, Z. Suhail, L. Harlow, J. Dai, K. G. Beaumont, R. Sebra, D. E. Willis, C. P. Cardozo and R. Iyengar, 2023. Spinal cord injury regulates circular RNA expression in axons. Front Mol Neurosci 16: 1183315. * uses Xona's silicone devices (SND450) with primary cortical neurons https://doi.org/10.3389%2Ffnmol.2023.1183315
Tags: cortical neurons, injury, mouse, primary, rat, SND450

Kaniyappan, S., Balaji, V., Wang, Y., Mandelkow, E., 2023. Microfluidic Chamber Technology to Study Missorting and Spreading of Tau Protein in Alzheimer’s Disease, in: Cieplak, A.S. (Ed.), Protein Aggregation: Methods and Protocols. New York, NY: Springer US, pp. 111-123. * uses Xona’s Silicone (PDMS) Devices (RD150, TCND1000) with primary rat cortical or hippocampal neurons **PROTOCOL** https://doi.org/10.1007/978-1-0716-2597-2_9
Tags: cortical neurons, hippocampal neurons, primary, protocol, rat, RD150, TCND1000

Higerd-Rusli, G.P., Tyagi, S., Baker, C.A., Liu, S., Dib-Hajj, F.B., Dib-Hajj, S.D., Waxman, S.G., 2023. Inflammation differentially controls transport of depolarizing Nav versus hyperpolarizing Kv channels to drive rat nociceptor activity. Proceedings of the National Academy of Sciences 120, e2215417120. https://www.pnas.org/doi/10.1073/pnas.2215417120
Tags: basic research, DOC450, postnatal, rat

Vevea, J.D., Chapman, E.R., 2023. Mitofusin 2 sustains the axonal mitochondrial network to support presynaptic Ca2+ homeostasis and the synaptic vesicle cycle in rat hippocampal axons. The Journal of Neuroscience, JN-RM-1356-1322. https://doi.org/10.1523/JNEUROSCI.1356-22.2023
Tags: basic research, hippocampal neurons, rat

Higerd-Rusli, G.P., Tyagi, S., Liu, S., Dib-Hajj, F.B., Waxman, S.G., Dib-Hajj, S.D., 2023. The fates of internalized NaV1.7 channels in sensory neurons: Retrograde cotransport with other ion channels, axon-specific recycling, and degradation. Journal of Biological Chemistry 299 * uses Xona’s Silicone Devices (DOC450) with primary rat DRGs (P2-4). https://doi.org/10.1016/j.jbc.2022.102816
Tags: basic research, DOC450, postnatal, rat

Subramani, M., Hook, M.V., Rajamoorthy, M., Qiu, F., Ahmad, I., 2023. Human Retinal Ganglion Cells Respond to Evolutionarily Conserved Chemotropic Cues for Intra Retinal Guidance and Regeneration. bioRxiv, 2023.2002.2001.526677 * uses Xona’s Silicone Devices (SND450) with human retinal ganglion cells and rat retinal cells.  https://doi.org/10.1101/2023.02.01.526677
Tags: human, preprint, rat, retinal ganglion cells, SND450

Shekari, A., Fahnestock, M., 2022. Retrograde axonal transport of Neurotrophins in basal forebrain cholinergic neurons, Axonal Transport: Methods and Protocols: Springer, pp. 249-270.  * uses XonaChips® (XC450) and ChipTrays with rat or mouse basal forebrain cholinergic neurons. **PROTOCOL** https://doi.org/10.1007/978-1-0716-1990-2_13
Tags: basal forebrain cholinergic neurons, ChipTray, mouse, protocol, rat, XC450

Danastas, K., Larsen, A., Jobson, S., Guo, G., Cunningham, A.L., Miranda-Saksena, M., 2022. Herpes simplex virus-1 utilizes the host actin cytoskeleton for its release from axonal growth cones. PLOS Pathogens 18, e1010264. * uses Xona’s Silicone Devices (SND450) with rat DRG neurons https://doi.org/10.1371/journal.ppat.1010264
Tags: DRG, rat, SND450

Harbauer, A.B., Hees, J.T., Wanderoy, S., Segura, I., Gibbs, W., Cheng, Y., Ordonez, M., Cai, Z., Cartoni, R., Ashrafi, G., Wang, C., Perocchi, F., He, Z., Schwarz, T.L., 2022. Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy. Neuron. * uses Xona’s Silicone Devices (RD450) with rat hippocampal neurons http://doi.org/10.1016/j.neuron.2022.01.035
Tags: hippocampal neurons, rat, RD450

Higerd-Rusli, G.P., Alsaloum, M., Tyagi, S., Sarveswaran, N., Estacion, M., Akin, E.J., Dib-Hajj, F.B., Liu, S., Sosniak, D., Zhao, P., Dib-Hajj, S.D., Waxman, S.G., 2022. Depolarizing NaV and Hyperpolarizing KV Channels Are Co-Trafficked in Sensory Neurons. The Journal of Neuroscience 42, 4794.   https://doi.org/10.1523/JNEUROSCI.0058-22.2022
Tags: DOC450, postnatal, rat, sensory neurons

Wang, T., Meunier, F.A., 2022. Live-Cell Superresolution Imaging of Retrograde Axonal Trafficking Using Pulse–Chase Labeling in Cultured Hippocampal Neurons, in: Shen, J. (Ed.), Membrane Trafficking: Methods and Protocols. New York, NY: Springer US, pp. 101-128. **PROTOCOL** 10.1007/978-1-0716-2209-4_9
Tags: hippocampal neurons, protocol, rat, RD450

Hansen, J., Siddiq, M.M., Yadaw, A.S., Tolentino, R.E., Rabinovich, V., Jayaraman, G., Jain, M.R., Liu, T., Li, H., Xiong, Y., Goldfarb, J., Iyengar, R., 2022. Whole cell response to receptor stimulation involves many deep and distributed subcellular biochemical processes. Journal of Biological Chemistry 298. * uses Xona’s Silicone Devices (SND150) with primary rat cortical neurons. https://doi.org/10.1016/j.jbc.2022.102325
Tags: cortical neurons, primary, rat, SND150

Hofmann, M., Biller, L., Michel, U., Bähr, M., Koch, J.C., 2022. Cytoskeletal assembly in axonal outgrowth and regeneration analyzed on the nanoscale. Sci Rep 12, 14387. * uses Xona’s Silicone Devices (SND450) with primary rat cortical neurons. https://doi.org/10.1038/s41598-022-18562-5
Tags: cortical neurons, primary, rat, SND450

Siddiq, M.M., Hannila, S.S., Zorina, Y., Nikulina, E., Rabinovich, V., Hou, J., Huq, R., Richman, E.L., Tolentino, R.E., Hansen, J., Velenosi, A., Kwon, B.K., Tsirka, S.E., Maze, I., Sebra, R., Beaumont, K.G., Toro, C.A., Cardozo, C.P., Iyengar, R., Filbin, M.T., 2021. Extracellular histones, a new class of inhibitory molecules of CNS axonal regeneration. Brain Communications, fcab271.* uses Xona’s Silicone Devices (SND150, SND450) with rat DRG neurons http://doi.org/10.1093/braincomms/fcab271
Tags: DRG, rat, SND150, SND450

Katiyar, N., Raju, G., Madhusudanan, P., Gopalakrishnan-Prema, V., Shankarappa, S.A., 2021. Neuronal delivery of nanoparticles via nerve fibres in the skin. Sci Rep 11, 2566.  * uses Xona’s Silicone Devices (SND150) with adult rat DRG neurons https://doi.org/10.1038/s41598-021-81995-x
Tags: adult, DRG, rat, SND150

Akin, E.J., Alsaloum, M., Higerd, G.P., Liu, S., Zhao, P., Dib-Hajj, F.B., Waxman, S.G., Dib-Hajj, S.D., 2021. Paclitaxel increases axonal localization and vesicular trafficking of Nav1.7. Brain. * uses Xona’s Silicone Devices (DOC450) with rat DRG neurons https://doi.org/10.1093/brain/awab113
Tags: DOC450, DRG, rat

Fukuda, Y., Pazyra-Murphy, M.F., Silagi, E.S., Tasdemir-Yilmaz, O.E., Li, Y., Rose, L., Yeoh, Z.C., Vangos, N.E., Geffken, E.A., Seo, H.-S., Adelmant, G., Bird, G.H., Walensky, L.D., Marto, J.A., Dhe-Paganon, S., Segal, R.A., 2020. Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival. Journal of Cell Biology 220. * uses XonaChips® (XC900), XonaPDL™, and Xona’s Silicone Devices (SND450) with rat DRG neurons https://doi.org/10.1083/jcb.202005051
Tags: DRG, rat, SND450, XC900, XonaPDL

Wang, T., Li, W., Martin, S., Papadopulos, A., Joensuu, M., Liu, C., Jiang, A., Shamsollahi, G., Amor, R., Lanoue, V., Padmanabhan, P., Meunier, F.A., 2020. Radial contractility of actomyosin rings facilitates axonal trafficking and structural stability. Journal of Cell Biology 219. * uses Xona’s Silicone Devices (RD450 and TCND500) with rat hippocampal neurons https://doi.org/10.1083/jcb.201902001
Tags: hippocampal neurons, rat, RD450, TCND500

Aravamudhan, P., Raghunathan, K., Konopka-Anstadt, J., Pathak, A., Sutherland, D.M., Carter, B.D., Dermody, T.S., 2020. Reovirus uses macropinocytosis-mediated entry and fast axonal transport to infect neurons. PLoS pathogens 16, e1008380-e1008380. PMID: 32109948 * uses XonaChips® (XC450) with rat DRG neurons  https://www.ncbi.nlm.nih.gov/pubmed/32109948
Tags: DRG, rat, XC450

Aravamudhan, P., Raghunathan, K., Dermody, T.S., 2020. Confocal Microscopy of Reovirus Transport in Living Dorsal Root Ganglion Neurons. Bio Protoc 10, e3825.  * uses XonaChips® (XC450) with rat DRG neurons http://doi.org/10.21769/BioProtoc.3825
Tags: DRG, rat, XC450

Zhang, Y., Qin, Y., Chopp, M., Li, C., Kemper, A., Liu, X., Wang, X., Zhang, L., Zhang Zheng, G., 2020. Ischemic Cerebral Endothelial Cell–Derived Exosomes Promote Axonal Growth. Stroke 51, 3701-3712. * uses Xona’s Silicone Devices (SND450, TCND500) with rat cortical neurons and exosomes isolated from cerebral endothelial cells (CECs) http://doi.org/10.1161/STROKEAHA.120.031728
Tags: cortical neurons, rat, SND450, TCND500

Li, C., Zhang, Y., Levin, A.M., Fan, B.Y., Teng, H., Ghannam, M.M., Chopp, M., Zhang, Z.G., 2019. Distal Axonal Proteins and Their Related MiRNAs in Cultured Cortical Neurons. Mol Neurobiol. Apr;56(4):2703-2713. doi: 10.1007/s12035-018-1266-7. * uses Xona’s Silicone Devices (SND450) with rat cortical neurons  https://www.ncbi.nlm.nih.gov/pubmed/30054858
Tags: cortical neurons, rat, SND450

Wang, L., Chopp, M., Lu, X., Szalad, A., Jia, L., Liu, X.S., Wu, K.-H., Lu, M., Zhang, Z.G., 2019. miR-146a mediates thymosin β4 induced neurovascular remodeling of diabetic peripheral neuropathy in type-II diabetic mice. Brain Res. Mar 15;1707:198-207. doi: 10.1016/j.brainres.2018.11.039 * uses Xona’s Silicone Devices (Cat. # not specified) with rat DRG neurons  https://www.ncbi.nlm.nih.gov/pubmed/30500399
Tags: DRG, rat, SND450

Pu, H., Shi, Y., Zhang, L., Lu, Z., Ye, Q., Leak, R.K., Xu, F., Ma, S., Mu, H., Wei, Z., Xu, N., Xia, Y., Hu, X., Hitchens, T.K., Bennett, M.V.L., Chen, J., 2019. Protease-independent action of tissue plasminogen activator in brain plasticity and neurological recovery after ischemic stroke. Proceedings of the National Academy of Sciences 116, 9115, doi: 10.1073/pnas.1821979116.* uses Xona’s Silicone Devices (SND450) with rat cortical neurons  https://www.ncbi.nlm.nih.gov/pubmed/30996120
Tags: cortical neurons, rat, SND450

Desforges, M., Le Coupanec, A., Dubeau, P., Bourgouin, A., Lajoie, L., Dubé, M., & Talbot, P. J. (2019). Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?. Viruses12(1), 14. https://doi.org/10.3390/v12010014 * uses XonaChips® (XC150) with murine mixed neurons  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020001/
Tags: cortical neurons, mouse, rat, XC150

Nagendran, T. & Taylor, A.M. (2019). Unique Axon-to-Soma Signaling Pathways Mediate Dendritic Spine Loss and Hyper-Excitability Post-axotomy. Front. Cell. Neurosci., 13(431), https://doi.org/10.3389/fncel.2019.00431 * uses Silicone Devices (SND900) with rat hippocampal neurons **Original research authored by Xona scientists**  https://www.frontiersin.org/articles/10.3389/fncel.2019.00431/full
Tags: hippocampal neurons, rat, SND900, Xona author

Vysokov, N., McMahon, S.B., Raouf, R., 2019. The role of NaV channels in synaptic transmission after axotomy in a microfluidic culture platform. Sci Rep 9, 12915. DOI: 10.1038/s41598-019-49214-w * uses Xona’s Silicone Devices (TCND1000) with rat DRG neurons and dorsal horn co-culture  https://www.nature.com/articles/s41598-019-49214-w
Tags: co-culture, dorsal horn, DRG, rat, TCND1000

Shekari, A. & Fahnestock, M. (2019). Retrograde axonal transport of BDNF and proNGF diminishes with age in basal forebrain cholinergic neurons. Neurobiol. Aging, 84: 131-140, https://doi.org/10.1016/j.neurobiolaging.2019.07.018 * uses XonaChips® (XC450) with rat basal forebrain or cortical neurons  https://www.ncbi.nlm.nih.gov/pubmed/31574357
Tags: basal forebrain cholinergic neurons, cortical neurons, rat, XC450

Barber, A.C., Evans, R.S., Nieuwenhuis, B., Pearson, C.S., Fuchs, J., MacQueen, A.R., Erp, S.v., Haenzi, B., Hulshof, L.A., Osborne, A., Conceicao, R., Deshpande, S.S., Cave, J., ffrench-Constant, C., Smith, P.D., Okkenhaug, K., Eickholt, B.J., Martin, K.R., Fawcett, J.W., Eva, R., 2019. PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS. bioRxiv, 787994. * uses Xona’s Silicone Devices (SND150) with rat DRG neurons  https://doi.org/10.1101/787994
Tags: DRG, rat, SND150

Van Laar, V. S., B. Arnold, E. H. Howlett, M. J. Calderon, C. M. St Croix, J. T. Greenamyre, L. H. Sanders and S. B. Berman, 2018. Evidence for Compartmentalized Axonal Mitochondrial Biogenesis: Mitochondrial DNA Replication Increases in Distal Axons As an Early Response to Parkinson's Disease-Relevant Stress. J Neurosci 38(34): 7505-7515. https://doi.org/10.1523/jneurosci.0541-18.2018
Tags: cortical neurons, rat, SND450, SND900

Nagendran, T., V. Poole, J. Harris and A. M. Taylor, 2018. Use of Pre-Assembled Plastic Microfluidic Chips for Compartmentalizing Primary Murine Neurons. Journal of visualized experiments : JoVE(141). * uses XC150, XC450, XC900 XonaChips with rat hippocampal neurons.  https://dx.doi.org/10.3791/58421
Tags: hippocampal neurons, mouse, protocol, rat, XC150, XC450, XC900, Xona author

Nagendran, T., R. S. Larsen, R. L. Bigler, S. B. Frost, B. D. Philpot, R. J. Nudo and A. M. Taylor, 2017. Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling. Nature Communications 8(1): 625. https://doi.org/10.1038/s41467-017-00652-y
Tags: hippocampal neurons, rat, SND450, SND900, Xona author

Westergard, T., Jensen, Brigid K., Wen, X., Cai, J., Kropf, E., Iacovitti, L., Pasinelli, P., Trotti, D., 2016. Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72-ALS/FTD. Cell Reports 17, 645-652. * uses Xona’s Silicone (PDMS) Devices (SND150) with primary rat cortical neurons https://doi.org/10.1016/j.celrep.2016.09.032
Tags: cortical neurons, primary, rat, SND150

Taylor, A. M., D. C. Dieterich, H. T. Ito, S. A. Kim and E. M. Schuman, 2010. Microfluidic local perfusion chambers for the visualization and manipulation of synapses. Neuron 66(1): 57-68. https://doi.org/10.1016/j.neuron.2010.03.022
Tags: hippocampal neurons, microfluidic local perfusion device, primary, rat, SND150, SND450, SND900, uLP, Xona author

Taylor, A. M., N. C. Berchtold, V. M. Perreau, C. H. Tu, N. Li Jeon and C. W. Cotman, 2009. Axonal mRNA in uninjured and regenerating cortical mammalian axons. The Journal of Neuroscience 29(15): 4697-4707. https://doi.org/10.1523/jneurosci.6130-08.2009
Tags: cortical neurons, injury, rat, SND900, Xona author

Taylor, A. M., S. W. Rhee and N. L. Jeon, 2006. Microfluidic chambers for cell migration and neuroscience research. Methods Mol Biol 321: 167-177. https://doi.org/10.1385/1-59259-997-4:167
Tags: hippocampal neurons, rat, Xona author

Park, J. W., B. Vahidi, A. M. Taylor, S. W. Rhee and N. L. Jeon, 2006. Microfluidic culture platform for neuroscience research. Nature protocols 1(4): 2128-2136. https://doi.org/10.1038/nprot.2006.316
Tags: hippocampal neurons, rat

Taylor, A. M., M. Blurton-Jones, S. W. Rhee, D. H. Cribbs, C. W. Cotman and N. L. Jeon, 2005. A microfluidic culture platform for CNS axonal injury, regeneration and transport. Nature Methods 2(8): 599-605. https://doi.org/10.1038/nmeth777
Tags: hippocampal neurons, rat, Xona author

Taylor, A. M., S. W. Rhee, C. H. Tu, D. H. Cribbs, C. W. Cotman and N. L. Jeon, 2003. Microfluidic Multicompartment Device for Neuroscience Research. Langmuir 19(5): 1551-1556.       https://doi.org/10.1021/la026417v
Tags: hippocampal neurons, rat, Xona author

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